Phenylpiperazine

Phenylpiperazine

Names
IUPAC name 1-phenylpiperazine
Identifiers
CAS Number	92-54-6
ChEMBL	ChEMBL9434
ChemSpider	6829
Jmol 3D model	Interactive image
PubChem	7096
InChI InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2 Key: YZTJYBJCZXZGCT-UHFFFAOYSA-N InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2 InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2 Key: YZTJYBJCZXZGCT-UHFFFAOYSA-N
SMILES c1cc(ccc1)N2CCNCC2
Properties
Chemical formula	C10H14N2
Molar mass	162.23 g/mol
Appearance	clear colourless to yellow liquid
Density	1.028g/cm^3
Melting point	18.8 °C (65.8 °F; 291.9 K)
Boiling point	287.2 °C (549.0 °F; 560.3 K) at 760mmHg
Solubility in water	insoluble
Hazards
Flash point	138.3 °C (280.9 °F; 411.4 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

1-Phenylpiperazine is a simple chemical compound featuring a phenyl group bound to a piperazine ring. The suffix ‘-piprazole’ is sometimes used in the names of drugs to indicate they belong to this class.^[1]

A number of phenylpiperazine derivatives are drugs, including:

Pharmaceuticals:

• Antrafenine — anti-inflammatory
• Aripiprazole — antipsychotic
• Bifeprunox — antipsychotic
• Brexpiprazole — antipsychotic
• Cariprazine — antipsychotic
• Ciprofloxacin — antibiotic
• Dapiprazole — alpha blocker
• Dropropizine — antitussive
• Elopiprazole — antipsychotic
• Etoperidone — antidepressant
• Itraconazole — antifungal
• Ketoconazole — antifungal
• Levodropropizine — antitussive
• Lubazodone — antidepressant
• Mepiprazole — anxiolytic
• Mianserin — antidepressant
• Naftopidil — antihypertensive
• Nefazodone — antidepressant
• Niaprazine — hypnotic
• Oxypertine — antipsychotic
• Posaconazole — antifungal
• Tioperidone — antipsychotic
• Tolpiprazole (Tranquilliser)
• Trazodone — antidepressant
• Umespirone — antipsychotic
• Urapidil — antihypertensive
• Vesnarinone — cardiotonic

Research chemicals:

• Acaprazine — anxiolytic
• Batoprazine — serenic (antiaggressive)
• Bifeprunox — antipsychotic
• BRL-15,572 — serotonergic
• CSP-2503 — anxiolytic
• DMPP — nicotinic
• EGIS-12,233 — serotonergic
• Elopiprazole — antipsychotic
• Eltoprazine — serenic
• Enpiprazole — anxiolytic
• Ensaculin — nootropic
• Flibanserin — aphrodisiac
• Fluprazine — serenic
• Flesinoxan — antidepressant
• Lorpiprazole — anxiolytic
• Naluzotan — antidepressant
• Naphthylpiperazine — serotonergic
• Pardoprunox — antiparkinsonian
• S-14,506 — serotonergic
• S-14,671 — serotonergic
• S-15,535 — serotonergic
• SB-258,585 — serotonergic
• SB-271,046 — serotonergic
• SB-357,134 — serotonergic
• SB-399,885 — serotonergic
• Sonepiprazole — dopaminergic
• Tolpiprazole — anxiolytic
• Vilazodone — antidepressant
• Vortioxetine — antidepressant
• WAY-100,135 — serotonergic
• WAY-100,635 — serotonergic
• Zolertine — antihypertensive

Designer drugs:

• DCPP — serotonergic
• mCPP — serotonergic
• MeOPP — serotonergic
• pCPP — serotonergic
• pFPP — serotonergic
• TFMPP — serotonergic

See also

• Benzylpiperazine
• Diphenylpiperazine
• Diphenylmethylpiperazine
• Pyridinylpiperazine
• Pyrimidinylpiperazine

References

1. World Health Organization (WHO) (2006). "The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances" (PDF). Retrieved April 2010.