SB-399885

SB-399885

Systematic (IUPAC) name
N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide
Identifiers
CAS Number	402713-80-8
PubChem	CID 6918649
IUPHAR/BPS	3241
ChEMBL	CHEMBL1210710
Chemical data
Formula	C18H21Cl2N3O4S
Molar mass	446.347 g/mol
SMILES C3CNCCN3c2cc(ccc2OC)S(=O)(=O)Nc(c1OC)cc(Cl)cc1Cl
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SB-399885 is a drug which is used in scientific research. It acts as a potent, selective and orally active 5-HT₆ receptor antagonist, with a Ki of 9.0nM. SB-399885 and other 5-HT₆ antagonists show nootropic effects in animal studies,^[1][2] as well as antidepressant and anxiolytic effects which are comparable to and synergistic with drugs such as imipramine and diazepam,^[3][4][5] and have been proposed as potential novel treatments for cognitive disorders such as schizophrenia^[6] and Alzheimer's disease.

References

1. Perez-García, G; Meneses, A (2005). "Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task". Pharmacology, Biochemistry, and Behavior 81 (3): 673–82. doi:10.1016/j.pbb.2005.05.005. PMID 15964617.
2. Hirst, WD; Stean, TO; Rogers, DC; Sunter, D; Pugh, P; Moss, SF; Bromidge, SM; Riley, G; et al. (2006). "SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models". European Journal of Pharmacology 553 (1–3): 109–19. doi:10.1016/j.ejphar.2006.09.049. PMID 17069795.
3. Wesołowska, A; Nikiforuk, A (2007). "Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression". Neuropharmacology 52 (5): 1274–83. doi:10.1016/j.neuropharm.2007.01.007. PMID 17320917.
4. Wesołowska, A (2008). "The anxiolytic-like effect of the selective 5-HT6 receptor antagonist SB-399885: the impact of benzodiazepine receptors". European Journal of Pharmacology 580 (3): 355–60. doi:10.1016/j.ejphar.2007.11.022. PMID 18096153.
5. Wesołowska, A; Nikiforuk, A (2008). "The selective 5-HT(6) receptor antagonist SB-399885 enhances anti-immobility action of antidepressants in rats". European Journal of Pharmacology 582 (1–3): 88–93. doi:10.1016/j.ejphar.2007.12.013. PMID 18234190.
6. Li, Z; Huang, M; Prus, AJ; Dai, J; Meltzer, HY (2007). "5-HT6 receptor antagonist SB-399885 potentiates haloperidol and risperidone-induced dopamine efflux in the medial prefrontal cortex or hippocampus". Brain Research 1134 (1): 70–8. doi:10.1016/j.brainres.2006.11.060. PMID 17207474.