1P-LSD

1P-LSD
Systematic (IUPAC) name
N,N-diethyl-7-methyl-4-propanoyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide
Clinical data
Legal status
  • Illegal in Denmark, Sweden and Switzerland
CAS Number none
Chemical data
Formula C23H29N3O2
Molar mass 379.22 g/mol

1P-LSD or 1-propionyl-lysergic acid diethylamide is a psychedelic drug of the lysergamide class that is an analog of LSD and homolog of ALD-52 and has been sold online as a designer drug.[1][2][3][4][5][6]

While 1P-LSD shows only 38% the potency of LSD in mice, LSD is detected via LC-MS when 1P-LSD is incubated in human serum,[7] meaning 1P-LSD not only acts as a prodrug for LSD, but is also a directly acting serotonin receptor agonist in its own right.[8][9]

Legal Status

1P-LSD is illegal in Denmark,[10] Sweden[11][12] and Switzerland.[13]

See also

References

  1. ↑ "Philtre Bulletin Issue 5" (PDF). WEDINOS. March 2015. Retrieved 28 July 2015.
  2. ↑ Max Daly (27 July 2015). "Why Young Brits Are Taking So Much LSD and Ecstasy". Vice. Retrieved 11 August 2015.
  3. ↑ "Yttrande enligt 13 § Lag (2011:111) om förstörande av vissa hälsofarliga missbrukssubstanser" (PDF) (in Swedish). Folkhälsomyndigheten. 24 June 2015. Retrieved 11 August 2015.
  4. ↑ "Newer Unregulated Drugs" (PDF). KFx. April 2015. Retrieved 13 August 2015.
  5. ↑ Matthew Speiser (11 August 2015). "A handful of dangerous new legal drugs has public health experts worried". Business Insider UK. Retrieved 13 August 2015.
  6. ↑ "1P-LSD". New Synthetic Drugs Database.
  7. ↑ Simon D. Brandt, Pierce V. Kavanagh, Folker Westphal, Alexander Stratford, Simon P. Elliott, Khoa Hoang, Jason Wallach, Adam L. Halberstadt (October 2015). "Return of the lysergamides. Part I: Analytical and behavioural characterization of 1-propionyl-d-lysergic acid diethylamide (1P-LSD)". Drug Testing and Analysis. doi:10.1002/dta.1884.
  8. ↑ Jose (15 October 2015). "Is 1P-LSD A Prodrug To LSD?". Detect-Kit. Retrieved 15 October 2015.
  9. ↑ P. Linda, A. Stener, A. Cipiciani, G. Savelli (January–February 1983). "Hydrolysis of amides. Kinetics and mechanism of the basic hydrolysis of N-acylpyrroles, N-acylindoles and N-acylcarbazoles". Journal of Heterocyclic Chemistry 20 (1): 247–248. doi:10.1002/jhet.5570200154.
  10. ↑ "Lists of euphoriant substances". The Danish Medicines Agency. September 2015.
  11. ↑ "31 nya ämnen kan klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 17 November 2015.
  12. ↑ "31 nya substanser klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 26 January 2016.
  13. ↑ "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Der Bundesrat.
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