1P-LSD

1P-LSD

Systematic (IUPAC) name
N,N-diethyl-7-methyl-4-propanoyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide
Clinical data
Legal status	Illegal in Denmark, Sweden and Switzerland
CAS Number	none
Chemical data
Formula	C23H29N3O2
Molar mass	379.22 g/mol
SMILES C(C)N(C(=O)C1CN(C2CC=3C4=C(C2=C1)C=CC=C4N(C3)C(CC)=O)C)CC
InChI InChI=1/C23H29N3O2/c1-5-21(27)26-14-15-12-20-18(17-9-8-10-19(26)22(15)17)11-16(13-24(20)4)23(28)25(6-2)7-3/h8-11,14,16,20H,5-7,12-13H2,1-4H3 Key:JSMQOVGXBIDBIE-UHFFFAOYSA-N

1P-LSD or 1-propionyl-lysergic acid diethylamide is a psychedelic drug of the lysergamide class that is an analog of LSD and homolog of ALD-52 and has been sold online as a designer drug.^{[1][2][3][4][5][6]}

While 1P-LSD shows only 38% the potency of LSD in mice, LSD is detected via LC-MS when 1P-LSD is incubated in human serum,^[7] meaning 1P-LSD not only acts as a prodrug for LSD, but is also a directly acting serotonin receptor agonist in its own right.^[8][9]

Legal Status

1P-LSD is illegal in Denmark,^[10] Sweden^[11][12] and Switzerland.^[13]

See also

• AL-LAD
• ETH-LAD
• LSM-775
• LSZ
• PRO-LAD

References

1. "Philtre Bulletin Issue 5" (PDF). WEDINOS. March 2015. Retrieved 28 July 2015.
2. Max Daly (27 July 2015). "Why Young Brits Are Taking So Much LSD and Ecstasy". Vice. Retrieved 11 August 2015.
3. "Yttrande enligt 13 § Lag (2011:111) om förstörande av vissa hälsofarliga missbrukssubstanser" (PDF) (in Swedish). Folkhälsomyndigheten. 24 June 2015. Retrieved 11 August 2015.
4. "Newer Unregulated Drugs" (PDF). KFx. April 2015. Retrieved 13 August 2015.
5. Matthew Speiser (11 August 2015). "A handful of dangerous new legal drugs has public health experts worried". Business Insider UK. Retrieved 13 August 2015.
6. "1P-LSD". New Synthetic Drugs Database.
7. Simon D. Brandt, Pierce V. Kavanagh, Folker Westphal, Alexander Stratford, Simon P. Elliott, Khoa Hoang, Jason Wallach, Adam L. Halberstadt (October 2015). "Return of the lysergamides. Part I: Analytical and behavioural characterization of 1-propionyl-d-lysergic acid diethylamide (1P-LSD)". Drug Testing and Analysis. doi:10.1002/dta.1884.
8. Jose (15 October 2015). "Is 1P-LSD A Prodrug To LSD?". Detect-Kit. Retrieved 15 October 2015.
9. P. Linda, A. Stener, A. Cipiciani, G. Savelli (January–February 1983). "Hydrolysis of amides. Kinetics and mechanism of the basic hydrolysis of N-acylpyrroles, N-acylindoles and N-acylcarbazoles". Journal of Heterocyclic Chemistry 20 (1): 247–248. doi:10.1002/jhet.5570200154.
10. "Lists of euphoriant substances". The Danish Medicines Agency. September 2015.
11. "31 nya ämnen kan klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 17 November 2015.
12. "31 nya substanser klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 26 January 2016.
13. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Der Bundesrat.