ADB-PINACA

ADB-PINACA

Systematic (IUPAC) name
N-(1-Amino-3,3-dimethyl-1-oxo-2-butanyl)-1-pentyl-1H-indazole-3-carboxamide
Clinical data
Legal status
Legal status	CA: Schedule II US: Schedule I
Identifiers
CAS Number	1633766-73-0
PubChem	CID 86280478
ChemSpider	29342129
Chemical data
Formula	C19H28N4O2
Molar mass	344.51 g/mol
SMILES CCCCCN1C2=CC=CC=C2C(=N1)C(=O)NC(C(=O)N)C(C)(C)C
InChI InChI=1S/C19H28N4O2/c1-5-6-9-12-23-14-11-8-7-10-13(14)15(22-23)18(25)21-16(17(20)24)19(2,3)4/h7-8,10-11,16H,5-6,9,12H2,1-4H3,(H2,20,24)(H,21,25) Key:FWTARAXQGJRQKN-UHFFFAOYSA-N

ADB-PINACA is a cannabinoid designer drug that is an ingredient in some synthetic cannabis products. It is a potent agonist of the CB₁ receptor and CB₂ receptor with a EC₅₀ value of 0.52 nM and 0.88 nM respectively.^[1][2]

Side effects

ADB-PINACA has been linked to multiple hospitalizations and deaths due to its use.^[3][4][5]

Legality

ADB-PINACA is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015.^[6]

In the United States, it is a Schedule I controlled substance.^[7]

As of October 2015 ADB-PINACA is a controlled substance in China.^[8]

See also

• 5F-AB-PINACA
• 5F-ADB
• 5F-ADB-PINACA
• 5F-AMB
• 5F-APINACA
• AB-FUBINACA
• AB-CHFUPYCA
• AB-CHMINACA
• AB-PINACA
• ADB-CHMINACA
• ADB-FUBINACA
• ADBICA
• APICA
• APINACA
• MDMB-CHMICA
• PX-3

References

1. Samuel D Banister, Michael Moir, Jordyn Stuart, Richard C Kevin, Katie E Wood, Mitchell Longworth, Shane M Wilkinson, Corinne Beinat, Alxendra S Buchanan, Michelle Glass, Mark Connor, Iain S McGregor, Michael Kassiou (July 2015). "The pharmacology of indole and indazole synthetic cannabinoid designer drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA and 5F-ADBICA". ACS Chemical Neuroscience 6: 1546–59. doi:10.1021/acschemneuro.5b00112. PMID 26134475.
2. "ADB-PINACA". Forendex.
3. "CDC: 221 sickened by synthetic pot in Colorado". USA Today. December 12, 2013.
4. Michael D. Schwartz; et al. (March 2015). "A Common Source Outbreak of Severe Delirium Associated with Exposure to the Novel Synthetic Cannabinoid ADB-PINACA". Journal of Emergency Medicine 48 (5): 573–580. doi:10.1016/j.jemermed.2014.12.038. PMID 25726258.
5. Jordan Trecki, Roy R. Gerona, Michael D. Schwartz (July 2015). "Synthetic Cannabinoid–Related Illnesses and Deaths". New England Journal of Medicine 373 (2): 103–107. doi:10.1056/NEJMp1505328. PMID 26154784.
6. "CNB NEWS RELEASE". Central Narcotics Bureau (CNB). 30 April 2015. Retrieved 24 July 2015.
7. "Schedules of controlled substances: temporary placement of four synthetic cannabinoids into Schedule I. Final order". Fed Regist. 79 (27): 7577–7582. Feb 10, 2014. PMID 24605391.
8. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.