AB-CHFUPYCA

AB-CHFUPYCA

Systematic (IUPAC) name
N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl)-1H -pyrazole-5-carboxamide
Legal status
Legal status	CA: Schedule II
CAS Number	none
Chemical data
Formula	C22H29FN4O2
Molar mass	400.50 g/mol
SMILES O=C(NC(C(N)=O)C(C)C)C1=CC(C2=CC=C(F)C=C2)=NN1CC3CCCCC3
InChI InChI=1S/C22H29FN4O2/c1-14(2)20(21(24)28)25-22(29)19-12-18(16-8-10-17(23)11-9-16)26-27(19)13-15-6-4-3-5-7-15/h8-12,14-15,20H,3-7,13H2,1-2H3,(H2,24,28)(H,25,29) Key:NDYOOVJIZQTGHY-UHFFFAOYSA-N

AB-CHFUPYCA (also AB-CHMFUPPYCA)^[1] is a compound that was first identified as a component of synthetic cannabis products in Japan in 2015.^[2][3] The name "AB-CHFUPYCA" is an acronym of its systematic name N-(1-Amino-3-methyl-1-oxoButan-2-yl)-1-(CycloHexylmethyl)-3-(4-FlUorophenyl)-1H-PYrazole-5-CarboxAmide.

Although AB-CHFUPYCA contains structural elements common to the synthetic cannabinoid designer drugs AB-PINACA and AB-FUBINACA, it can also be considered an analog of the traditional pyrazole cannabinoid receptor 1 antagonist rimonabant. Its pharmacological properties have been the subject of only very limited study; it is presumed to be a potent agonist of the CB₁ receptor.

See also

• 5F-AB-FUPPYCA
• 5F-AB-PINACA
• 5F-ADB
• 5F-AMB
• 5F-APINACA
• AB-CHMFUPPYCA
• AB-FUBINACA
• AB-PINACA
• ADB-CHMINACA
• ADB-FUBINACA
• ADB-PINACA
• ADBICA
• APICA
• APINACA
• MDMB-CHMICA
• Rimonabant

References

1. Gavin McLaughlin, Noreen Morris, Pierce V. Kavanagh, John D. Power, Brendan Twamley, John O'Brien, Brian Talbot, Geraldine Dowling, Simon D. Brandt (September 2015). "The synthesis and characterization of the ‘research chemical’ N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide (3,5-AB-CHMFUPPYCA) and differentiation from its 5,3-regioisomer". Drug Testing and Analysis. doi:10.1002/dta.1864.
2. Uchiyama, N.; Asakawa, K.; Kikura-Hanajiri, R.; Tsutsumi, T.; Hakamatsuka, T. (August 2015). "A new pyrazole-carboxamide type synthetic cannabinoid AB-CHFUPYCA [N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide] identified in illegal products". Forensic Toxicology 33 (2): 367–373. doi:10.1007/s11419-015-0283-8.
3. Florian Franz, Verena Angerer, Simon D. Brandt, Gavin McLaughlin, Pierce V. Kavanagh, Bjoern Moosmann, Volker Auwärter (2016). "In vitro metabolism of the synthetic cannabinoid 3,5-AB-CHMFUPPYCA and its 5,3-regioisomer and investigation of their thermal stability". Drug Testing and Analysis. doi:10.1002/dta.1950.