MDMB-CHMICA

MDMB-CHMICA
Systematic (IUPAC) name
methyl 2-{[1-(cyclohexylmethyl)-1H-indol-3-yl]formamido}-3,3-dimethylbutanoate
Clinical data
Legal status
  • CA: Schedule II
  • DE: Anlage II (Prohibited)
  • Illegal in Austria, China, Louisiana, Sweden & Switzerland
Identifiers
CAS Number 1715016-78-6
ChemSpider 34450863
UNII H2HEN05B8P YesY
Chemical data
Formula C23H32N2O3
Molar mass 384.51 g/mol

MDMB-CHMICA (also incorrectly known as MMB-CHMINACA) is an indole-based synthetic cannabinoid that is a potent agonist of the CB1 receptor and has been sold online as a designer drug.[1][2] Ironically while MDMB-CHMICA was initially sold under the name "MMB-CHMINACA", the compound corresponding to this code name (i.e. the isopropyl instead of t-butyl analogue of MDMB-CHMINACA) has never been identified on the designer drug market as of 2015.[3]

40 kg of MDMB-CHMICA was seized in Luxembourg in December 2014.[4]

Side Effects

There have been a number of reported cases of deaths and hospitalizations in relation to this synthetic cannabinoid.[5][6][7][8]

Metabolism

MDMB-CHMICA appears to have a similar metabolic fate as AB-CHMINACA.[9]

Legal status

On October 29, 2014 the state of Louisiana emergency scheduled MDMB-CHMICA into Schedule I.[10]

MDMB-CHMICA falls into Anlage II of the Neue Psychoaktive Substanzen Gesetz (NPSG) and is therefore illegal in Austria.[11]

MDMB-CHMICA is an Anlage II controlled drug in Germany.[12]

Sweden's public health agency suggested classifying MDMB-CHMICA as hazardous substance on November 10, 2014.[13]

As of October 2015 MDMB-CHMICA is a controlled substance in China.[14]

MDMB-CHMICA is illegal in Switzerland as of December 2015.[15]

See also

References

  1. ↑ "MDMB-CHMICA". Cayman Chemical. Retrieved 29 June 2015.
  2. ↑ "MDMB-CHMICA". Southern Association of Forensic Scientists. Retrieved 29 June 2015.
  3. ↑ Shevyrin V, Melkozerov V, Nevero A, Eltsov O, Shafran Y, Morzherin Y, Lebedev AT (Apr 2015). "Identification and analytical characteristics of synthetic cannabinoids with an indazole-3-carboxamide structure bearing a N-1-methoxycarbonylalkyl group". Analytical and Bioanalytical Chemistry 407: 6301–15. doi:10.1007/s00216-015-8612-7. PMID 25893797.
  4. ↑ "Global SMART update" (PDF). United Nations Office on Drugs and Crime. 13 March 2015. Retrieved 29 June 2015.
  5. ↑ "[EWS Alert]: 2 deaths and 3 non-fatal intoxications in Germany associated with MDMB-CHMICA (methyl-2-(1-(cyclohexylmethyl)-1 H-indol-3-ylcarbonylamino)-3,3-dimethylbutanoate)". EMCDDA. 27 April 2015. Retrieved 29 June 2015.
  6. ↑ "Derby legal high confusion prompts police warning". BBC. 29 April 2015. Retrieved 29 June 2015.
  7. ↑ "Drug Alert: Dangerous Synthetic Cannabinoid MMB-CHMINACA Causing Hospitalizations, Deaths in Europe". TalkingDrugs. 2 July 2015. Retrieved 2 July 2015.
  8. ↑ Andreas Austgulen Westin, Joachim Frost, Wenche Rødseth Brede, Per Ole M. Gundersen, Steinar Einvik, Harald Aarset, Lars Slørdal (February 2016). "Sudden Cardiac Death Following Use of the Synthetic Cannabinoid MDMB-CHMICA". Journal of Analytical Toxicology 40 (1): 86–87. doi:10.1093/jat/bkv110. PMID 26353925.
  9. ↑ Florian Franz, Nadja Schwörer, Verena Angerer, Bjoern Moosmann, Volker Auwärter (2015). "Metabolism and urine analysis of the new synthetic cannabinoid MDMB-CHMICA" (PDF). Toxichem Krimtech 82: 192.
  10. ↑ "Gov. Jindal and State Officials Ban New Synthetic Marijuana Compound". Retrieved 29 June 2015.
  11. ↑ "Räuchermischung "Bonzai": Was steckt dahinter?" (in German). Initiative Suchtprävention. 17 December 2014. Retrieved 29 June 2015.
  12. ↑ "44. Sitzung des Sachverständigenausschusses" (in German). Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM). 17 April 2015. Retrieved 29 June 2015.
  13. ↑ "Cannabinoider föreslås bli klassade som hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. Retrieved 29 June 2015.
  14. ↑ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
  15. ↑ "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Der Bundesrat.


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