AR-231,453

AR-231,453

Systematic (IUPAC) name
N-(2-fluoro-4-methanesulfonylphenyl)-(6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitropyrimidin-4-yl)amine
Identifiers
PubChem	CID 24939268
IUPHAR/BPS	5653
ChemSpider	23330691
ChEMBL	CHEMBL461384
Chemical data
Formula	C21H24FN7O5S
Molar mass	505.522 g/mol
SMILES Fc2cc(S(=O)(C)=O)ccc2Nc1ncnc(c1N(=O)=O)N(CC3)CCC3c(n4)onc4C(C)C
InChI InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25) Key:DGBKNTVAKIFYNU-UHFFFAOYSA-N
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AR-231,453 is an agonist for the suggested novel cannabinoid receptor GPR119.^[1]

See also

• PSN-375,963
• PSN-632,408

References

1. Semple G, Fioravanti B, Pereira G, Calderon I, Uy J, Choi K, Xiong Y, Ren A, Morgan M, Dave V, Thomsen W, Unett DJ, Xing C, Bossie S, Carroll C, Chu ZL, Grottick AJ, Hauser EK, Leonard J, Jones RM. (2008). "Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119.". J Med Chem. 51 (17): 5172–5175. doi:10.1021/jm8006867. PMID 18698756.