5F-PB-22

5F-PB-22

Systematic (IUPAC) name
1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester
Clinical data
Legal status
Legal status	CA: Schedule II DE: Anlage II (Prohibited) US: Schedule I
Identifiers
CAS Number	1400742-41-7
ChemSpider	29341631
Chemical data
Formula	C23H21FN2O2
Molar mass	376.42 g/mol
SMILES C1=CC=C2C(=C1)C(=CN2CCCCCF)C(=O)OC3=CC=CC4=C3N=CC=C4
InChI InChI=1S/C23H21FN2O2/c24-13-4-1-5-15-26-16-19(18-10-2-3-11-20(18)26)23(27)28-21-12-6-8-17-9-7-14-25-22(17)21/h2-3,6-12,14,16H,1,4-5,13,15H2 Key:MBOCMBFDYVSGLJ-UHFFFAOYSA-N

5F-PB-22 (5F-QUPIC or Quinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate) is a designer drug which acts as a cannabinoid agonist.^[1] The structure of 5F-PB-22 appears to have been designed with an understanding of structure-activity relationships within the indole class of cannabinoids.^[2]

Legal Status

As of October 2015 5F-PB-22 is a controlled substance in China.^[3]

In January 2014, 5F-PB-22 was designated as a Schedule I controlled substance in the United States after several deaths were associated with its use.^[4][5]

See also

• AM-2201
• JWH-018
• QUCHIC
• QUPIC
• SDB-001
• SDB-005

References

1. Banister, S. D.; Stuart, J.; Kevin, R. C.; Edington, A.; Longworth, M.; Wilkinson, S. M.; Beinat, C.; Buchanan, A. S.; Hibbs, D. E.; Glass, M.; Connor, M.; McGregor, I. S.; Kassiou, M. (2015). "Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135". ACS Chemical Neuroscience 6 (8): 150508124201002. doi:10.1021/acschemneuro.5b00107.
2. "5F-PB-22". Forendex. Retrieved 24 June 2015.
3. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
4. Behonick, G; Shanks, K. G.; Firchau, D. J.; Mathur, G; Lynch, C. F.; Nashelsky, M; Jaskierny, D. J.; Meroueh, C (2014). "Four Postmortem Case Reports with Quantitative Detection of the Synthetic Cannabinoid, 5F-PB-22". Journal of analytical toxicology 38 (8): 559–62. doi:10.1093/jat/bku048. PMC 4334789. PMID 24876364.
5. Jordan Trecki, Roy R. Gerona, Michael D. Schwartz (July 2015). "Synthetic Cannabinoid–Related Illnesses and Deaths". New England Journal of Medicine 373 (2): 103–107. doi:10.1056/NEJMp1505328. PMID 26154784.