PF-3845

PF-3845

Systematic (IUPAC) name
N-3-pyridinyl-4-([3-([5-(trifluoromethyl)-2-pyridinyl]oxy)phenyl]methyl)-1-piperidinecarboxamide
Clinical data
Legal status	Investigational New Drug
Identifiers
CAS Number	1196109-52-0
ATC code	None
PubChem	CID 25154867
Chemical data
Formula	C24H23F3N4O2
Molar mass	456.459 g/mol
SMILES O=C(NC1=CN=CC=C1)N(CC2)CCC2CC3=CC=CC(OC4=NC=C(C(F)(F)F)C=C4)=C3

PF-3845 is a selective inhibitor of fatty acid amide hydrolase.^[1] It results in increased levels of anandamide and results in cannabinoid receptor-based effects. It has anti-inflammatory action in mice colitis models. Antidiarrheal and antinociceptive effects were also seen in mouse models of pain.^[2]

References

1. Ahn, K; Johnson, DS; Mileni, M; Beidler, D; Long, JZ; McKinney, MK; Weerapana, E; Sadagopan, N; Liimatta, M; Smith, SE; Lazerwith, S; Stiff, C; Kamtekar, S; Bhattacharya, K; Zhang, Y; Swaney, S; Van Becelaere, K; Stevens, RC; Cravatt, BF (24 April 2009). "Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.". Chemistry & Biology 16 (4): 411–20. doi:10.1016/j.chembiol.2009.02.013. PMID 19389627.
2. Fichna, J.; Sałaga, M.; Stuart, J.; Saur, D.; Sobczak, M.; Zatorski, H.; Timmermans, J.-P.; Bradshaw, H. B.; Ahn, K. (2014-04-01). "Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides". Neurogastroenterology and Motility: The Official Journal of the European Gastrointestinal Motility Society 26 (4): 470–481. doi:10.1111/nmo.12272. ISSN 1365-2982. PMID 24460851.