5F-PCN

5F-PCN

Systematic (IUPAC) name
1-(5-fluoropentyl)-N-(naphthalen-1-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide
Legal status
Legal status	CA: Schedule II
CAS Number	None
Chemical data
Formula	C23H22FN3O
Molar mass	375.4 g/mol
SMILES O=C(NC1=C(C=CC=C2)C2=CC=C1)C3=CN(CCCCCF)C4=C3C=NC=C4
InChI InChI=1S/C23H22FN3O/c24-12-4-1-5-14-27-16-20(19-15-25-13-11-22(19)27)23(28)26-21-10-6-8-17-7-2-3-9-18(17)21/h2-3,6-11,13,15-16H,1,4-5,12,14H2,(H,26,28) Key:BRRZRRZUERBDQL-UHFFFAOYSA-N

5F-PCN (also known as 5-F-MN-21) is an azaindole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB₁ receptor and has been sold online as a designer drug.^[1][2] It is closely related to NNE1. Given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, it is suspected that metabolic hydrolysis of the amide group of 5F-PCN may release 1-naphthylamine, a known carcinogen.

Legal status

Sweden's public health agency suggested to classify 5F-PCN as hazardous substance on November 10, 2014.^[3]

See also

• 5F-NNE1
• AM-2201
• APICA
• CUMYL-PICA
• JWH-018
• NM-2201
• SDB-005

References

1. "5F-PCN". Cayman Chemical. Retrieved 22 July 2015.
2. Antoni R. Blaazer; et al. (October 2011). "Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: Design, synthesis, structure–activity relationships, physicochemical properties and biological activity". European Journal of Medicinal Chemistry 46 (10): 5086–5098. doi:10.1016/j.ejmech.2011.08.021. PMID 21885167.
3. "Cannabinoider föreslås bli klassade som hälsofarlig vara". Folkhälsomyndigheten. Retrieved 22 July 2015.