AM-855

AM-855

Systematic (IUPAC) name
(4aR,12bR)-8-hexyl-2,5,5-trimethyl-1,4,4a,8,9,10,11,12b-octahydronaphtho[3,2-c]isochromen-12-ol
Identifiers
CAS Number	249888-50-4
PubChem	CID 10091328
ChemSpider	8266865
ChEMBL	CHEMBL303479
Chemical data
Formula	C26H38O2
Molar mass	382.577 g/mol
SMILES Oc1c4C2CC(C)=CCC2C(C)(C)Oc4cc3c1CCCC3CCCCCC
InChI InChI=1S/C26H38O2/c1-5-6-7-8-10-18-11-9-12-19-20(18)16-23-24(25(19)27)21-15-17(2)13-14-22(21)26(3,4)28-23/h13,16,18,21-22,27H,5-12,14-15H2,1-4H3/t18?,21-,22-/m1/s1 Key:GAAJNVWIOIOMPO-IPKCRJEZSA-N
(verify)

AM-855 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ⁸Tetrahydrocannabinol with a conformationally restricted side chain which has been bound into a fourth ring fused to the aromatic A-ring of the cannabinoid skeleton. AM-855 is an agonist at both CB₁ and CB₂ with moderate selectivity for CB₁, with a K_i of 22.3nM at CB₁ and 58.6nM at CB₂.^[1]

References

1. Khanolkara, Atmaram D.; Lua, Dai; Fana, Pusheng; Tiana, Xiaoyu; Makriyannis, Alexandros (August 1999). "Novel conformationally restricted tetracyclic analogs of Δ⁸-tetrahydrocannabinol". Bioorganic & Medicinal Chemistry Letters 9 (15): 2119–24. doi:10.1016/S0960-894X(99)00355-8. PMID 10465529.