5F-NNE1

5F-NNE1

Systematic (IUPAC) name
1-(5-Fluoropentyl)-N-(naphthalen-1-yl)-1H-indole-3-carboxamide
Clinical data
Legal status	CA: Schedule II
Identifiers
CAS Number	1445580-60-8
ChemSpider	29341632
UNII	3T22QDP4D9
Chemical data
Formula	C24H23FN2O
Molar mass	374.45 g/mol
SMILES FCCCCCn1cc(c2c1cccc2)C(=O)Nc1cccc2c1cccc2
InChI InChI=1S/C24H23FN2O/c25-15-6-1-7-16-27-17-21(20-12-4-5-14-23(20)27)24(28)26-22-13-8-10-18-9-2-3-11-19(18)22/h2-5,8-14,17H,1,6-7,15-16H2,(H,26,28) Key:DJKVOBZLMBHFKX-UHFFFAOYSA-N

5F-NNE1 (also known as 5F-NNEI and 5F-MN-24) is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB₁ receptor and has been sold online as a designer drug.^[1][2] Given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, it is suspected that metabolic hydrolysis of the amide group of 5F-NNE1 may release 1-naphthylamine, a known carcinogen.

Legality

Sweden's public health agency suggested classifying 5F-NNE1 as hazardous substance on November 10, 2014.^[3]

See also

• 5F-ADBICA
• 5F-SDB-006
• AM-2201
• FDU-NNE1
• FUB-144
• FUB-NNE1
• MMB-2201
• NNE1
• PX-1

References

1. "5F-NNEI". Southern Association of Forensic Scientists. Retrieved 24 July 2015.
2. Ariane Wohlfarth, Marisol S. Castaneto, Mingshe Zhu, Shaokun Pang, Karl B. Scheidweiler, Robert Kronstrand, Marilyn A. Huestis (May 2015). "Pentylindole/Pentylindazole Synthetic Cannabinoids and Their 5-Fluoro Analogs Produce Different Primary Metabolites: Metabolite Profiling for AB-PINACA and 5F-AB-PINACA". The AAPS Journal 17 (3): 660–677. doi:10.1208/s12248-015-9721-0. PMID 25721194.
3. "Cannabinoider föreslås bli klassade som hälsofarlig vara". Folkhälsomyndigheten. Retrieved 24 July 2015.