JWH-196

JWH-196

Systematic (IUPAC) name
2-methyl-3-(1-naphthalenylmethyl)-1-pentyl-1H-Indole
Clinical data
Legal status	UK: Class B
Identifiers
CAS Number	619294-41-6
ChemSpider	35303441
Chemical data
Formula	C25H27N
Molar mass	341.49 g/mol
SMILES CCCCCn1c(c(c2c1cccc2)Cc3cccc4c3cccc4)C
InChI InChI=1S/C25H27N/c1-3-4-9-17-26-19(2)24(23-15-7-8-16-25(23)26)18-21-13-10-12-20-11-5-6-14-22(20)21/h5-8,10-16H,3-4,9,17-18H2,1-2H3 Key:LDTJKFUAZQDSQS-UHFFFAOYSA-N

JWH-196 is a synthetic cannabinoid receptor ligand from the naphthoylindole family. It is the indole 2-methyl derivative of related compound JWH-175, and the carbonyl reduced analog of JWH-007. The binding affinity of JWH-196 for the CB₁ receptor is reported as K_i = 151 ± 18 nM.^[1]

See also

• JWH-007
• JWH-175

References

1. Huffman JW, Mabon R, Wu M-J, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR (2003). "3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor". Bioorg. Med. Chem. 11 (4): 539–549. doi:10.1016/s0968-0896(02)00451-0.