Eticyclidine

Eticyclidine

Systematic (IUPAC) name
N-ethyl-1-phenylcyclohexylamine
Clinical data
Legal status
Legal status	AU: S9 (Prohibited) CA: Schedule I DE: Anlage I (Controlled) UK: Class B US: Schedule I
Identifiers
CAS Number	2201-15-2
ATC code	none
PubChem	CID 16622
ChemSpider	15759
UNII	O8I1LL6A89
ChEMBL	CHEMBL279924
Chemical data
Formula	C14H21N
Molar mass	203.323 g/mol
SMILES CCNC1(CCCCC1)C2=CC=CC=C2
InChI InChI=1S/C14H21N/c1-2-15-14(11-7-4-8-12-14)13-9-5-3-6-10-13/h3,5-6,9-10,15H,2,4,7-8,11-12H2,1H3 Key:IFYLVUHLOOCYBG-UHFFFAOYSA-N
(verify)

Eticyclidine (PCE, CI-400) is a dissociative anesthetic drug with hallucinogenic effects. It is similar in effects to phencyclidine but is slightly more potent. PCE was developed by Parke-Davis in the 1970s and evaluated for anesthetic potential under the code name CI-400,^[1] but research into PCE was not continued after the development of ketamine, a similar drug with more favourable properties.^[2] PCE is slightly more potent than PCP and has similar effects, but its unpleasant taste and tendency to cause nausea made it less accepted by users.^[3] Due to its similarity in effects to PCP, PCE was placed into the Schedule 1 list of illegal drugs in the 1970s, although it was only briefly abused in the 1970s and 1980s and is now little known.

See also

• Arylcyclohexylamine
• 3-MeO-PCE
• 3-MeO-PCP
• 4-MeO-PCP
• Phencyclidine
• PCPr
• Methoxetamine

References

1. LEVY L, CAMERON DE, AITKEN RC (March 1960). "Observation on two psychotomimetic drugs of piperidine derivation--CI 395 (sernyl) and CI 400". The American Journal of Psychiatry 116: 843–4. PMID 14416411.
2. Kalir A, Edery H, Pelah Z, Balderman D, Porath G. 1-Phenylcycloalkylamine derivatives. II. Synthesis and pharmacological activity. Journal of Medicinal Chemistry. 1969. 12(3):473-477
3. Structure Activity of PCP analogs