Dexoxadrol

Dexoxadrol

Systematic (IUPAC) name
(2S)-2-[(4S)-2,2-di(phenyl)-1,3-dioxolan-4-yl]piperidine
Clinical data
Legal status	Legal
Identifiers
CAS Number	6495-46-1
ATC code	none
PubChem	CID 3034023
ChemSpider	2298576
UNII	Verifiedfields = changed JY5N9F45AG Verifiedfields = changed
ChEMBL	CHEMBL1165411
Chemical data
Formula	C20H23NO2
Molar mass	309.40 g/mol
SMILES O1C[C@@H](OC1(c2ccccc2)c3ccccc3)[C@H]4NCCCC4
InChI InChI=1S/C20H23NO2/c1-3-9-16(10-4-1)20(17-11-5-2-6-12-17)22-15-19(23-20)18-13-7-8-14-21-18/h1-6,9-12,18-19,21H,7-8,13-15H2/t18-,19+/m0/s1 Key:HGKAMARNFGKMLC-RBUKOAKNSA-N
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Dexoxadrol (Dioxadrol) is a dissociative anaesthetic drug which has been found to be an NMDA antagonist and produces similar effects to PCP in animals. Dexoxadrol, along with another related drug etoxadrol, were developed as analgesics for use in humans, but development was discontinued after patients reported side effects such as nightmares and hallucinations.^[1][2]

See also

• Etoxadrol

References

1. Sax, M.; Wünsch, B. (2006). "Relationships between the structure of dexoxadrol and etoxadrol analogues and their NMDA receptor affinity". Current Topics in Medicinal Chemistry 6 (7): 723–732. doi:10.2174/156802606776894483. PMID 16719812.
2. Aepkers, M.; Wünsch, B. (2005). "Structure-affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol". Bioorganic and Medicinal Chemistry 13 (24): 6836–6849. doi:10.1016/j.bmc.2005.07.030. PMID 16169732.