Bithionol

Bithionol
Systematic (IUPAC) name


2,2'-sulfanediylbis(4,6-dichlorophenol)
Identifiers
CAS Number	97-18-7^N
ATC code	D10AB01 (WHO) P02BX01 QP52AG07
PubChem	CID 2406
IUPHAR/BPS	2338
DrugBank	DB04813^Y
ChemSpider	2313^Y
UNII	AMT77LS62O^Y
ChEBI	CHEBI:3131^Y
ChEMBL	CHEMBL290106^Y
Synonyms	2,4-dichloro- 6-(3,5-dichloro- 2-hydroxyphenyl)sulfanylphenol
Chemical data
Formula	C₁₂H₆Cl₄O₂S
Molar mass	356.05 g/mol
SMILES Clc2cc(Cl)cc(Sc1cc(Cl)cc(Cl)c1O)c2O
InChI InChI=1S/C12H6Cl4O2S/c13-5-1-7(15)11(17)9(3-5)19-10-4-6(14)2-8(16)12(10)18/h1-4,17-18H^Y Key:JFIOVJDNOJYLKP-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Bithionol is an anthelmintic used to treat Anoplocephala perfoliata (tapeworms) in horses^[1] and Fasciola hepatica (liver flukes).

References

↑ Sanada Y, Senba H, Mochizuki R, Arakaki H, Gotoh T, Fukumoto S, Nagahata H (2009). "Evaluation of Marked Rise in Fecal Egg Output after Bithionol Administration to Horse and its Application as a Diagnostic Marker for Equine Anoplocephala perfoliata Infection" (pdf). Journal of Veterinary Medical Science 71 (5): 617–620. doi:10.1292/jvms.71.617. PMID 19498288.

Antiparasitics – Anthelmintics (P02) and Endectocides (QP54)

Antiplatyhelmintic agents

Antitrematodals
(schistosomicides)

Binds tubulin	benzimidazole Triclabendazole^#

AI	phosphonic acid Metrifonate^‡

Other/unknown	quinoline Praziquantel^# Oxamniquine^# phenol Bithionol thiazole Niridazole arylsulfonate Stibophen

Anticestodals
(taeniacides)

Binds tubulin	benzimidazole Albendazole^#

Other/unknown	quinoline Praziquantel^# salicylanilide Niclosamide^# aminoacridine Quinacrine butyrophenone Desaspidin chlorophenol Dichlorophen

Antinematodal agents
(including
macrofilaricides)

Binds tubulin	benzimidazole Mebendazole^# Albendazole^# Tiabendazole Fenbendazole Ciclobendazole Flubendazole

Glutamate-gated chloride channel, GABA receptor	avermectins Abamectin Doramectin Emamectin Ivermectin^# Selamectin milbemycins Moxidectin Milbemycin oxime

NMDA	tetrahydropyrimidine Pyrantel^# pyrantel pamoate Oxantel Morantel Carbantel Febantel (aka felsantel)

Other/unknown	piperazine Piperazine Diethylcarbamazine^# thiazole Levamisole^‡# quinolinium Pyrvinium benzylammonium Bephenium naphthalenesulfonate Suramin^# Tribendimidine

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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