Doramectin
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| Systematic (IUPAC) name | |
|---|---|
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(1'R,2S,4'S,5S,6R,8'R,10'E,12'R,13'S,14'E,20'R,21'R,24'S)-6-cyclohexyl-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-5,6-dihydro-3',7',19'-trioxaspiro[pyran-2,6'-tetracyclo[15.6.1.14,8.020,24]pentacosane]-10',14',16',22'-tetraen-2'-one | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Injection, Topical and Oral |
| Legal status |
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| Identifiers | |
| CAS Number | 117704-25-3 |
| ATCvet code | QP54AA03(WHO) |
| PubChem | CID 9832750 |
| ChemSpider |
8008478  |
| UNII |
KGD7A54H5P |
| KEGG |
D01129 |
| Chemical data | |
| Formula | C50H74O14 |
| Molar mass | 899.114 |
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Doramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle.[1]
It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of ivermectin. Its spectrum includes: Haemonchus spp., Ostertagia spp., Trichostrongylus spp., Cooperia spp., Oesophagostomum spp., Dictyocaulus viviparus, Dermatobia hominis, Boophilus microplus, Psoroptes bovis, among many other internal and external parasites. It is available in 2 dosage forms: as an injection and as a 5 mg/ml topical solution.
Doramectin is also marketed in many Latin-American and some Asia and Africa countries as Doramec L.A. (manufactured by Agrovet Market Animal Health[2]) in an 1% Doramectin Long Acting Injectable Solution for cattle, sheep, swine[3] and others. Its oleous carrier confers to Doramec L.A. a slow and prolonged liberation, extending its action up to 42 days.
Doramectin is also available for horses[3] as an oral flavored bioadhesive gel under the name Doraquest L.A. Oral Gel.[4] It can be used to control and treat internal parasites as roundworms, lungworms and some external parasites.
References
- ↑ Pfizer Animal Health. "DECTOMAX Injectable." Last accessed July 14, 2007.
- ↑ Agrovet Market Animal Health-Doramec L.A.
- 1 2 Agrovet Market Animal Health
- ↑ Agrovet Market Animal Health-Doraquest L.A. Oral Gel
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