Pyrantel
 | |
 | |
| Names | |
|---|---|
| IUPAC name
1-Methyl-2-[(E)-2-(2-thienyl)vinyl]-5,6-dihydro-4H-pyrimidine | |
| Identifiers | |
15686-83-6  | |
| ChEBI | CHEBI:8654  |
| ChEMBL | ChEMBL1626223 |
| Jmol interactive 3D | Image |
| KEGG | D08451 |
| MeSH | Pyrantel |
| PubChem | 708857 |
| UNII | 4QIH0N49E7 |
| |
| Properties | |
| C11H14N2S | |
| Molar mass | 206.31 g/mol |
| Pharmacology | |
| ATC code | P02 QP52AF02 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| verify (what is ?) | |
| Infobox references | |
Pyrantel is an antinematodal thiophene. It is often prescribed by veterinarians to treat and prevent the occurrence of intestinal parasites in small animal pets.
It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system.[1]
Mechanism of action
Pyrantel is a nicotinic receptor agonist.[2][3] Like levamisole and the related pyrimidine morantel, it can elicit spastic muscle paralysis in parasitic worms due to prolonged activation of the excitatory nicotinic acetylcholine (nACh) receptors on body wall muscle. This has been studied in body wall muscle preparation of the parasitic nematode Ascaris.[4]
See also
References
- ↑ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
- ↑ Aceves, J., Erlij, D., and Martinez-Maranon, R. (1970). The mechanism of the paralysing action of tetramisole on Ascaris somatic muscle. Br. J. Pharmacol. 38, 602–607.
- ↑ Aubry, M.L., Cowell, P., Davey, M.J., and Shevde, S. (1970). Aspects of the pharmacology of a new anthelmintic: pyrantel. Br. J. Pharmacol. 38, 332–344.
- ↑ Martin, R.J., Verma, S., Levandoski, M., Clark, C.L., Qian, H., Stewart, M., and Robertson, A.P. (2005). Drug resistance and neurotransmitter receptors of nematodes: recent studies on the mode of action of levamisole. Parasitology 131, S71–S84.
| ||||||||||||||||||||||||||||||||||||||||||||||||||
This article is issued from Wikipedia - version of the Friday, January 15, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.