CNQX

CNQX

Names
IUPAC name 7-nitro-2,3-dioxo-1,4- dihydroquinoxaline-6-carbonitrile
Identifiers
CAS Number	115066-14-3
ChEMBL	ChEMBL222418
ChemSpider	2951930
IUPHAR/BPS	5475
Jmol interactive 3D	Image
KEGG	C13668
PubChem	3721046
UNII	6OTE87SCCW
InChI InChI=1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15) Key: RPXVIAFEQBNEAX-UHFFFAOYSA-N InChI=1/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15) Key: RPXVIAFEQBNEAX-UHFFFAOYAV
SMILES [O-][N+](=O)c1c(C#N)cc2c(c1)NC(=O)C(=O)N2
Properties
Chemical formula	C9H4N4O4
Molar mass	232.15 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) is a competitive AMPA/kainate receptor antagonist. Its chemical formula is C₉H₄N₄O₄. CNQX is often used in the retina to block the responses of OFF-bipolar cells for electrophysiology recordings.^[1]

See also

• Quinoxalinedione

References

1. Sasaki, Tsugihisa; Kaneko, Akimichi (1996-03-01). "l-Glutamate-induced responses in OFF-type bipolar cells of the cat retina". Vision Research 36 (6): 787–795. doi:10.1016/0042-6989(95)00176-X.

External links

• Imamachi et al. : The Non-NMDA Glutamate Receptor Antagonist CNQX Augments Lidocaine Antinociception Through a Spinal Action in Rats
• Chemical structure