Thozalinone

Thozalinone

Systematic (IUPAC) name
(RS)-2-(Dimethylamino)-5-phenyl-1,3-oxazol-4(5H)-one
Clinical data
Routes of administration	Oral
Legal status	℞ (Prescription only)
Identifiers
CAS Number	655-05-0
ATC code	none
PubChem	CID 12602
ChemSpider	12082
UNII	68X5932947
KEGG	D06115
Synonyms	Tozalinone, Thozalinon
Chemical data
Formula	C11H12N2O2
Molar mass	204.225 g/mol
Chirality	Racemic mixture
SMILES O=C2\N=C(/OC2c1ccccc1)N(C)C
InChI InChI=1S/C11H12N2O2/c1-13(2)11-12-10(14)9(15-11)8-6-4-3-5-7-8/h3-7,9H,1-2H3 Key:JJSHYECKYLDYAR-UHFFFAOYSA-N
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Thozalinone (USAN) (brand name Stimsen; former developmental code name CL-39808) is a psychostimulant that has been used as an antidepressant in Europe.^{[1][2][3][4][5]} It has also been trialed as an anorectic.^[6] Thozalinone is described as a "dopaminergic stimulant",^[7] and likely acts via inducing the release of dopamine and norepinephrine similarly to its analogues pemoline and aminorex.^[2][8][9]

See also

• Fenozolone

References

1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 435–. ISBN 978-1-4757-2085-3.
2. Greenblatt EN, Osterberg AC (July 1965). "Some pharmacologic properties of thozalinone, a new excitant". Toxicology and Applied Pharmacology 7 (4): 566–78. doi:10.1016/0041-008X(65)90042-6. PMID 4378772.
3. Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
4. Merck index on CD-ROM: Windows. London: Chapman & Hall EPD. 1998. ISBN 0-412-82910-X.
5. Gallant DM, Bishop MP, Scrignar CB, Hornsby L, Moore B, Inturrisi BB (December 1966). "A double-blind study of thozalinone (C1 39,808) in depressed outpatients". Current Therapeutic Research, Clinical and Experimental 8 (12): 621–2. PMID 4962734.
6. Leite AC, Liepen LL, Costa VP (September 1971). "[Clinical trial of Stimsem Thozalinone in the treatment of obese patients]". Revista Brasileira De Medicina (in Portuguese) 28 (9): 475–8. PMID 5139648.
7. Yen-koo, H. C.; Balazs, T. (2015). "Detection of Dopaminergic Supersensitivity Induced by Neuroleptic Drugs in Mice". Drug and Chemical Toxicology 3 (2): 237–247. doi:10.3109/01480548009108286. ISSN 0148-0545.
8. Yen-Koo HC, Balazs T (1980). "Detection of dopaminergic supersensitivity induced by neuroleptic drugs in mice". Drug and Chemical Toxicology 3 (2): 237–47. doi:10.3109/01480548009108286. PMID 6112126.
9. Yen-Koo HC, Davis DA, Balazs T (1985). "Inhibition of dopaminergic agonist-induced gnawing behavior by neuroleptic drugs in mice". Drug and Chemical Toxicology 8 (6): 495–502. doi:10.3109/01480548509041072. PMID 2868876.