Ajmalicine
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| Systematic (IUPAC) name | |
|---|---|
|
(19α)-16,17-didehydro- 19-methyloxayohimban- 16-carboxylic acid methyl ester | |
| Clinical data | |
| Routes of administration | Oral |
| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number |
483-04-5  |
| ATC code | none |
| PubChem | CID 251561 |
| ChemSpider |
390541  |
| ChEMBL |
CHEMBL123325 |
| Chemical data | |
| Formula | C21H24N2O3 |
| Molar mass | 352.43 g/mol |
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Ajmalicine, also known as δ-yohimbine or raubasine, is an antihypertensive drug used in the treatment of high blood pressure.[1] It has been marketed under numerous brand names including Card-Lamuran, Circolene, Cristanyl, Duxil, Duxor, Hydroxysarpon, Iskedyl, Isosarpan, Isquebral, Lamuran, Melanex, Raunatin, Saltucin Co, Salvalion, and Sarpan.[1] It is also an alkaloid found naturally in various plants such as Rauwolfia spp., Catharanthus roseus, and Mitragyna speciosa.[1][2][3]
Ajmalicine is structurally related to yohimbine, rauwolscine, and other yohimban derivatives. Like corynanthine, it acts as a α1-adrenergic receptor antagonist with preferential actions over α2-adrenergic receptors, underlying its hypotensive rather than hypertensive effects.[1][4]
See also
References
- 1 2 3 4 Wink, Michael; Roberts, M. W. (1998). Alkaloids: biochemistry, ecology, and medicinal applications. New York: Plenum Press. ISBN 0-306-45465-3.
- ↑ Kurz WG, Chatson KB, Constabel F; et al. (May 1981). "Alkaloid Production in Catharanthus roseus Cell Cultures VIII1". Planta Medica 42 (5): 22–31. doi:10.1055/s-2007-971541. PMID 17401876.
- ↑ León F, Habib E, Adkins JE, Furr EB, McCurdy CR, Cutler SJ (July 2009). "Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A". Natural Product Communications 4 (7): 907–10. PMID 19731590.
- ↑ Roquebert J, Demichel P (October 1984). "Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine". European Journal of Pharmacology 106 (1): 203–5. doi:10.1016/0014-2999(84)90698-8. PMID 6099269.
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