Guanoxan

Guanoxan
Systematic (IUPAC) name

2-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)guanidine
Identifiers
CAS Number	2165-19-7^Y
ATC code	C02CC03 (WHO)
PubChem	CID 16564
ChemSpider	15704^N
UNII	9V0MRL0R5Y^Y
Chemical data
Formula	C₁₀H₁₃N₃O₂
Molar mass	207.23 g/mol
SMILES c1ccc2c(c1)OCC(O2)CNC(=N)N
InChI InChI=1S/C10H13N3O2/c11-10(12)13-5-7-6-14-8-3-1-2-4-9(8)15-7/h1-4,7H,5-6H2,(H4,11,12,13)^N Key:HIUVKVDQFXDZHU-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Guanoxan is a sympatholytic drug.

Sympatholytic (and closely related) antihypertensives (C02)

Sympatholytics
(antagonize α-adrenergic
vasoconstriction)

Central

α₂ agonist	Clonidine Guanabenz Guanfacine Methyldopa^# Tiamenidine^‡

Adrenergic release inhibitors	Bethanidine Bretylium Debrisoquine Guanadrel Guanazodine Guanethidine Guanoclor Guanazodine Guanoxabenz Guanoxan

Imidazoline receptor agonist	Moxonidine Rilmenidine

Ganglion-blocking/nicotinic antagonist	Hexamethonium^‡ Mecamylamine Pentolinium Trimethaphan

Peripheral

Indirect

MAOI	Pargyline^‡

Adrenergic uptake inhibitor	Bietaserpine Deserpidine Methoserpidine Rescinnamine Reserpine

Tyrosine hydroxylase inhibitor	Metirosine

Direct

α₁ blockers	Prazosin Indoramin Trimazosin Doxazosin Urapidil

Non-selective α blocker	Phentolamine

Other antagonists

Serotonin antagonist	Ketanserin Lidanserin

Endothelin antagonist (for PH)	dual (Bosentan, Macitentan) selective (Ambrisentan, Sitaxentan)

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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