Dopexamine

Dopexamine

Systematic (IUPAC) name
4-[2-({6-[(2-phenylethyl)amino]hexyl}amino)ethyl]benzene-1,2-diol
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	86197-47-9
ATC code	C01CA14 (WHO)
PubChem	CID 55483
ChemSpider	50102
UNII	398E7Z7JB5
KEGG	D03891
ChEMBL	CHEMBL77622
Chemical data
Formula	C22H32N2O2
Molar mass	429.43 g/mol
SMILES Oc1ccc(cc1O)CCNCCCCCCNCCc2ccccc2
InChI InChI=1S/C22H32N2O2/c25-21-11-10-20(18-22(21)26)13-17-24-15-7-2-1-6-14-23-16-12-19-8-4-3-5-9-19/h3-5,8-11,18,23-26H,1-2,6-7,12-17H2 Key:RYBJORHCUPVNMB-UHFFFAOYSA-N
(verify)

Dopexamine is a synthetic analogue of dopamine. Despite this, it is a β₁ and β₂ adrenoreceptor agonist.^[1] Its agonism of peripheral^[2] D₁ dopamine receptors mediates relaxation of vascular smooth muscle in renal, mesenteric, cerebral and coronary arteries. Mild action at D₂ receptors decreases norepinephrine (noradrenaline) release.

Use in sepsis has been proposed.^[3]

It is used as an inotropic agent in cardiac failure.^[4] Side effects include arrhythmia, tremor, angina and flushing.

References

1. Perrin G, Papazian L, Martin C. (1993). "Dopexamine: a new dopaminergic agonist". Ann Fr Anesth Reanim. 12 (3): 308–320. PMID 7902685.
2. Brown RA, Dixon J, Farmer JB; et al. (July 1985). "Dopexamine: a novel agonist at peripheral dopamine receptors and beta 2-adrenoceptors". Br. J. Pharmacol. 85 (3): 599–608. doi:10.1111/j.1476-5381.1985.tb10554.x. PMC 1916510. PMID 2862944.
3. Birnbaum J, Klotz E, Spies CD; et al. (2006). "Effects of dopexamine on the intestinal microvascular blood flow and leucocyte activation in a sepsis model in rats". Crit Care 10 (4): R117. doi:10.1186/cc5011. PMC 1750974. PMID 16893450.
4. Lisbon A (May 2003). "Dopexamine, dobutamine, and dopamine increase splanchnic blood flow: what is the evidence?". Chest 123 (5 Suppl): 460S–3S. doi:10.1378/chest.123.5_suppl.460S. PMID 12740229.