G-130

G-130

Systematic (IUPAC) name
2-phenyl-5,5-dimethylmorpholine
Identifiers
CAS Number	42013-48-9
PubChem	CID 97711
ChemSpider	88190
Chemical data
Formula	C12H17NO
Molar mass	191.269 g/mol
SMILES CC1(C)NCC(OC1)C2=CC=CC=C2
InChI InChI=1S/C12H17NO/c1-12(2)9-14-11(8-13-12)10-6-4-3-5-7-10/h3-7,11,13H,8-9H2,1-2H3 Key:KJUOROGOOZJYAI-UHFFFAOYSA-N
(verify)

G-130 (GP-130, 2-Phenyl-5,5-dimethyltetrahydro-1,4-oxazine)^[1] is a drug with stimulant and anorectic effects, related to phenmetrazine.^[2][3][4]

Structural analogs

Compounds related to G 130 and radafaxine were synthesized that behave as combined inhibitors of monoamine uptake and nAChRs.^[5]

See also

• 2-Phenyl-3,6-dimethylmorpholine
• 3-Fluorophenmetrazine
• Phendimetrazine (2-Phenyl-3,4-dimethylmorpholine)
• Manifaxine
• Radafaxine

References

1. GB 1336732  - Diethanolamine Derivatives.
2. Fanelli O (June 1973). "Pharmacological and toxicological study of a new psychotropic stimulant: the 2-phenyl-5-dimethyl-tetrahydro-1,4-oxazine, in comparison with d,l-amphetamine, phenmetrazine and pemoline-Mg". Arzneimittel-Forschung 23 (6): 810–6. PMID 4740767.
3. Fanelli O, Mazzoncini V, Ferri S (October 1974). "Toxicological and teratological study of 2-phenyl-5,5-dimethyl-tetrahydro-1,4-oxazine hydrochloride (G 130), a psychostimulant drug". Arzneimittel-Forschung 24 (10): 1627–32. PMID 4479774.
4. Fanelli O, Mazzoncini V, Trallori L (December 1974). "Antagonism of psychostimulant 2-phenyl-5,5-dimethyl-tetrahydro-1,4-oxazine hydrochloride (G 130) to central nervous system depressing drugs. Monoamine oxidase inhibitory activity and norepinephrine and serotonin induced changes. Comparison with dL-amphetamine". Arzneimittel-Forschung 24 (12): 2025–9. PMID 4480283.
5. Carroll, F. I.; Muresan, A. Z.; Blough, B. E.; Navarro, H. N. A.; Mascarella, S. W.; Eaton, J. B.; Huang, X.; Damaj, M. I.; Lukas, R. J. (2011). "Synthesis of 2-(Substituted Phenyl)-3,5,5-trimethylmorpholine Analogues and Their Effects on Monoamine Uptake, Nicotinic Acetylcholine Receptor Function, and Behavioral Effects of Nicotine". Journal of Medicinal Chemistry 54 (5): 1441–1448. doi:10.1021/jm1014555. PMC 3048909. PMID 21319801.