Almoxatone

Almoxatone

Systematic (IUPAC) name
(5R)-3-{4-[(3-chlorobenzyl)oxy]phenyl}-5-[(methylamino)methyl]-1,3-oxazolidin-2-one
Clinical data
Legal status	Uncontrolled
Identifiers
CAS Number	84145-89-1
ATC code	none
PubChem	CID 172287
ChemSpider	150582
UNII	85V47MCE4Z
ChEMBL	CHEMBL2104006
Chemical data
Formula	C18H19ClN2O3
Molar mass	346.81 g/mol
SMILES Clc1cccc(c1)COc3ccc(N2C(=O)O[C@H](CNC)C2)cc3
InChI InChI=1S/C18H19ClN2O3/c1-20-10-17-11-21(18(22)24-17)15-5-7-16(8-6-15)23-12-13-3-2-4-14(19)9-13/h2-9,17,20H,10-12H2,1H3/t17-/m1/s1 Key:KYXSTSXVEXKFJI-QGZVFWFLSA-N
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Almoxatone (MD-780,236) is a selective and reversible inhibitor of MAO-B.^[1][2] It was patented as an antidepressant and antiparkinsonian agent but was never marketed.^[3]

See also

• Monoamine oxidase inhibitor

References

1. Tipton KF, Fowler CJ, McCrodden JM, Strolin Benedetti M (January 1983). "The enzyme-activated irreversible inhibition of type-B monoamine oxidase by 3-(4-[(3-chlorophenyl)methoxy]phenyl)-5-[(methylamino) methyl]-2-oxazolidinone methanesulphonate (compound MD 780236) and the enzyme-catalysed oxidation of this compound as competing reactions". The Biochemical Journal 209 (1): 235–42. PMC 1154077. PMID 6847610.
2. Dostert P, Strolin Benedetti M, Guffroy C (March 1983). "Different stereoselective inhibition of monoamine oxidase-B by the R- and S-enantiomers of MD 780236". The Journal of Pharmacy and Pharmacology 35 (3): 161–5. doi:10.1111/j.2042-7158.1983.tb04297.x. PMID 6132973.
3. David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.