L-745,870

L-745,870

Systematic (IUPAC) name
3-([4-(4-chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo[2,3-b]pyridine
Identifiers
CAS Number	158985-00-3
PubChem	CID 5311200
IUPHAR/BPS	3303
ChemSpider	4470720
ChEMBL	CHEMBL267014
Chemical data
Formula	C18H19ClN4
Molar mass	326.822 g/mol
SMILES c1cc2c(c[nH]c2nc1)CN3CCN(CC3)c4ccc(cc4)Cl c2cc(Cl)ccc2N(CC3)CCN3Cc1cnc4c1cccn4
InChI InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21) Key:OGJGQVFWEPNYSB-UHFFFAOYSA-N
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L-745,870 is a drug which acts as a dopamine receptor antagonist selective for the D₄ subtype, and has antipsychotic effects in animal models, though it was not effective in human trials.^[1][2][3]

References

1. Bristow LJ, Kramer MS, Kulagowski J, Patel S, Ragan CI, Seabrook GR (June 1997). "Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist". Trends in Pharmacological Sciences 18 (6): 186–8. doi:10.1016/s0165-6147(97)01066-3. PMID 9226994.
2. Zhang K, Grady CJ, Tsapakis EM, Andersen SL, Tarazi FI, Baldessarini RJ (September 2004). "Regulation of working memory by dopamine D4 receptor in rats". Neuropsychopharmacology 29 (9): 1648–55. doi:10.1038/sj.npp.1300491. PMID 15138447.
3. Moustgaard A, Hau J, Lind NM (2008). "Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats". Behavioral and Brain Functions 4: 49. doi:10.1186/1744-9081-4-49. PMC 2577092. PMID 18945334.