SB-357134

SB-357134

Systematic (IUPAC) name
N-(2,5-Dibromo-3-fluorophenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide
Identifiers
PubChem	CID 6918553
IUPHAR/BPS	3235
ChemSpider	5293750
ChEMBL	CHEMBL329383
Chemical data
Formula	C17H18Br2FN3O3S
Molar mass	523.214 g/mol
SMILES C3CNCCN3c1cc(ccc1OC)S(=O)(=O)Nc2cc(Br)cc(F)c2Br
InChI InChI=1S/C17H18Br2FN3O3S/c1-26-16-3-2-12(10-15(16)23-6-4-21-5-7-23)27(24,25)22-14-9-11(18)8-13(20)17(14)19/h2-3,8-10,21-22H,4-7H2,1H3 Key:BLWHAZZXRHTFJE-UHFFFAOYSA-N
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SB-357134 is a drug which is used in scientific research. It acts as a potent, selective and orally active 5-HT₆ receptor antagonist.^[1] SB-357134 and other 5-HT₆ antagonists show nootropic effects in animal studies,^[2][3][4] and have been proposed as potential novel treatments for cognitive disorders such as schizophrenia and Alzheimer's disease.

References

1. Bromidge, SM; Clarke, SE; Gager, T; Griffith, K; Jeffrey, P; Jennings, AJ; Joiner, GF; King, FD; et al. (2001). "Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134)". Bioorganic & Medicinal Chemistry Letters 11 (1): 55–8. doi:10.1016/S0960-894X(00)00597-7. PMID 11140733.
2. Rogers, DC; Hagan, JJ (2001). "5-HT6 receptor antagonists enhance retention of a water maze task in the rat". Psychopharmacology 158 (2): 114–9. doi:10.1007/s002130100840. PMID 11702084.
3. Stean, TO; Hirst, WD; Thomas, DR; Price, GW; Rogers, D; Riley, G; Bromidge, SM; Serafinowska, HT; et al. (2002). "Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT(6) receptor antagonist". Pharmacology, Biochemistry, and Behavior 71 (4): 645–54. doi:10.1016/S0091-3057(01)00742-0. PMID 11888556.
4. Perez-García, G; Meneses, A (2005). "Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task". Pharmacology, Biochemistry, and Behavior 81 (3): 673–82. doi:10.1016/j.pbb.2005.05.005. PMID 15964617.