JNJ-7777120

JNJ-7777120

Systematic (IUPAC) name
5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-indole
Identifiers
CAS Number	459168-41-3
PubChem	CID 4908365
IUPHAR/BPS	1278
ChemSpider	4090750
ChEMBL	CHEMBL129198
Synonyms	1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine
Chemical data
Formula	C14H16ClN3O
Molar mass	277.749 g/mol
SMILES C3CN(C)CCN3C(=O)c(cc1c2)nc1ccc2Cl
InChI InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3 Key:HUQJRYMLJBBEDO-UHFFFAOYSA-N
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JNJ-7777120 is a drug being developed by Johnson & Johnson Pharmaceutical Research & Development which acts as a potent and selective antagonist at the histamine H₄ receptor.^[1] It has anti-inflammatory effects,^[2] and has been demonstrated to be superior to traditional antihistamines in the treatment of pruritus (itching).^[3]

See also

• VUF-6002

References

1. Jiang W, Lim HD, Zhang M, et al. (July 2008). "Cloning and pharmacological characterization of the dog histamine H(4) receptor". Eur. J. Pharmacol. 592 (1–3): 26–32. doi:10.1016/j.ejphar.2008.06.095. PMID 18639542.
2. Thurmond RL, Desai PJ, Dunford PJ, Fung-Leung WP, Hofstra CL, Jiang W, Nguyen S, Riley JP, Sun S, Williams KN, Edwards JP, Karlsson L. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. Journal of Pharmacology and Experimental Therapeutics. 2004 Apr;309(1):404-13. PMID 14722321
3. Dunford PJ, Williams KN, Desai PJ, Karlsson L, McQueen D, Thurmond RL. Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. Journal of Allergy and Clinical Immunology. 2007 Jan;119(1):176-83. PMID 17208599