Fipexide

Fipexide

Systematic (IUPAC) name
1-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]- 2-(4-chlorophenoxy)ethanone
Identifiers
CAS Number	34161-24-5
ATC code	N06BX05 (WHO)
PubChem	CID 3351
ChemSpider	3234
UNII	TG44VME01D
KEGG	D07345
ChEMBL	CHEMBL254857
Chemical data
Formula	C20H21ClN2O4
Molar mass	388.845 g/mol
SMILES Clc4ccc(OCC(=O)N1CCN(CC1)Cc2ccc3OCOc3c2)cc4
InChI InChI=1S/C20H21ClN2O4/c21-16-2-4-17(5-3-16)25-13-20(24)23-9-7-22(8-10-23)12-15-1-6-18-19(11-15)27-14-26-18/h1-6,11H,7-10,12-14H2 Key:BFUJHVVEMMWLHC-UHFFFAOYSA-N
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Fipexide (Attentil, Vigilor) is a psychoactive drug of the piperazine chemical class which was developed in Italy in 1983.^[1] It was used as a nootropic drug in Italy and France, mainly for the treatment of senile dementia,^[2] but is no longer in common use due to the occurrence of rare adverse drug reactions including fever^[3] and hepatitis. Fipexide is similar in action to other nootropic drugs such as piracetam and is structurally similar to another more well-known nootropic, centrophenoxine. Chemically, it is an amide union of parachlorophenoxyacetate and methylenedioxybenzylpiperazine (MDBZP), and has been shown to metabolize to the latter, which plays a significant role in its effects.

See also

• Befuraline
• Piberaline

References

1. Missale C, Pasinetti G, Govoni S, Spano PF, Trabucchi M. Fipexide: a new drug for the regulation of dopaminergic system at the macromolecular level. Bollettino Chimico Farmaceutico. 1983 Feb;122(2):79-85.
2. Bompani R, Scali G. Fipexide, an effective cognition activator in the elderly: a placebo-controlled, double-blind clinical trial. Current Medical Research and Opinion. 1986;10(2):99-106.
3. Guy C, Blay N, Rousset H, Fardeau V, Ollagnier M. Fever caused by fipexide. Evaluation of the national pharmacovigilance survey. Therapie. 1990 Sep-Oct;45(5):429-31.