Lidoflazine

Lidoflazine

Systematic (IUPAC) name
2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	3416-26-0
ATC code	C08EX01 (WHO)
PubChem	CID 3926
ChemSpider	3789
UNII	J4ZHN3HBTE
KEGG	D04733
Chemical data
Formula	C30H35F2N3O
Molar mass	491.615 g/mol
SMILES CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
InChI InChI=1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36) Key:ZBIAKUMOEKILTF-UHFFFAOYSA-N
Physical data
Melting point	159 to 161 °C (318 to 322 °F)
Solubility in water	Almost insoluble in water(<0.01%); Very soluble in chloroform(>50%); mg/mL (20 °C)
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Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action.^[1] Lidoflazine was discovered at Janssen Pharmaceutica in 1964.

Physical properties

Solubility at room temperature

Extracted from ^[2]

Solvent	0.01 N		0.1 N
		%	pH	%	pH
Hydrochloric Acid	0.4	3.0	0.7	1.9
Tartaric Acid	0.3	3.1	1.0	2.5
Citric Acid	0.3	3.1	0.5	2.5
Lactic Acid	0.2	3.4	0.7	2.9
Acetic Acid	0.1	3.5	0.4	3.8

References

1. Schaper, W.K.A.; Xhonneux, R.; Jageneau, A.H.M.; Janssen, P.A.J. (1966). "The cardiovascular pharmacology of lidoflazine, a long-acting coronary vasodilator". Journal of Pharmacology and Experimental Therapeutics 152 (2): 265–274. PMID 5944369. Retrieved 2009-06-20.
2. http://jpet.aspetjournals.org/cgi/content/abstract/152/2/265

• Schaper WK, Xhonneux R, Jageneau AH., Stimulation of the coronary collateral circulation by lidoflazine (R 7904), Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 November 4;252(1):1-8.