Prazitone

Prazitone

Systematic (IUPAC) name
5-phenyl-5-(piperidin-2-ylmethyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Identifiers
CAS Number	2409-26-9
ATC code	none
PubChem	CID 3050417
ChemSpider	2312482
UNII	6DZB018428
Synonyms	5-phenyl-5-(2-piperidylmethyl)barbituric acid
Chemical data
Formula	C16H19N3O3
Molar mass	301.34 g/mol
SMILES C1CCNC(C1)CC2(C(=O)NC(=O)NC2=O)C3=CC=CC=C3
InChI InChI=1S/C16H19N3O3/c20-13-16(11-6-2-1-3-7-11,14(21)19-15(22)18-13)10-12-8-4-5-9-17-12/h1-3,6-7,12,17H,4-5,8-10H2,(H2,18,19,20,21,22) Key:UGZAKKMLMJITLL-UHFFFAOYSA-N
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Prazitone (AGN-511) is a barbiturate derivative developed in the 1970s.^[1] Unlike most barbiturates, it has little or no sedative effects, instead acting as a non-sedating anxiolytic and antidepressant.^[2] The dosage range in humans is around 200–600 mg, although higher doses have been used in trials for the treatment of depression associated with Parkinson's disease.

References

1. DE Patent 1645911
2. Ross Langlands. Method for imparting anti-depressant and/or anxiolytic effects to animals. US Patent 3,806,596