Clobenpropit
 | |
| Systematic (IUPAC) name | |
|---|---|
|
N'-[(4-chlorophenyl)methyl]-1-[3-(3H-imidazol-4-yl)propylsulfanyl]formamidine | |
| Clinical data | |
| Legal status |
|
| Identifiers | |
| CAS Number | 145231-45-4 |
| ATC code | None |
| PubChem | CID 2790 |
| IUPHAR/BPS | 1223 |
| ChemSpider | 2688 |
| ChEMBL | CHEMBL14690 |
| Chemical data | |
| Formula | C14H17ClN4S |
| Molar mass | 308.83 g/mol |
| |
Clobenpropit is a histamine H3 receptor antagonist.[1] It has neuroprotective effects via stimulation of GABA release in the brain.[2]
See also
References
- ↑ Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). "The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes". European Journal of Pharmacology 567 (3): 206–210. doi:10.1016/j.ejphar.2007.04.032. PMID 17537431.
- ↑ Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z (2007). "The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons". European Journal of Pharmacology 563 (1-3): 117–123. doi:10.1016/j.ejphar.2007.01.069. PMID 17350613.
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