Drotaverine
Not to be confused with doravirine.
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| Systematic (IUPAC) name | |
|---|---|
|
(Z)-1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline | |
| Clinical data | |
| Trade names | No-Spa |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral, intravenous, intramuscular |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | Highly variable (~65%), peak at 45–60 min |
| Protein binding | 95–98% |
| Metabolism | Hepatic |
| Biological half-life | 7–16 hours |
| Excretion | >50% in urine and ~30% in bile[1] |
| Identifiers | |
| CAS Number |
985-12-6  |
| ATC code | A03AD02 (WHO) |
| PubChem | CID 1712095 |
| DrugBank |
DB06751 |
| ChemSpider |
1361582 |
| UNII |
98QS4N58TW |
| KEGG |
D07879 |
| ChEMBL |
CHEMBL551978 |
| Chemical data | |
| Formula | C24H31NO4 |
| Molar mass | 397.507 g/mol |
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Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, used to enhance cervical dilation during childbirth.[2]:283
It is structurally related to papaverine, is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.[3]
It is available in Asian and Eastern European countries under several brand names, with No-Spa being one of them.[4][5]
See also
References
- 1 2 "Инструкция по применению препарата Но-шпа® // No-Spa® (tablets) Full Prescribing Information". National Register of Drugs (in Russian). Chinoin Pharmaceutical and Chemical Works. pp. 3–8.
- ↑ Padubidri V and Anand E. Title Textbook of Obstetrics. BI Publications Pvt Ltd, 2006 ISBN 9788172252236
- ↑ "The DrugBank database: Drotaverine". DrugBank Version 4.1. The Metabolomics Innovation Centre. Retrieved 9 August 2014.
- ↑ Drotaverine - Drugs.com Drugs.com international listings for drotaverine Page accessed June 28, 2015
- ↑ No-Spa - Drugs.com No-Spa contents
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