Codeine 3-O-demethylase
Codeine 3-O-demethylase (EC 1.14.11.32, codeine O-demethylase, CODM) is an enzyme with systematic name codeine,2-oxoglutarate:oxygen oxidoreductase (3-O-demethylating).[1] This enzyme catalyses the following chemical reaction
- codeine + 2-oxoglutarate + O2
morphine + formaldehyde + succinate + CO2
Codeine 3-O-demethylase contains Fe2+.
References
- ↑ Hagel, J.M. and Facchini, P.J. (2010). "Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy". Nat. Chem. Biol. 6 (4): 273–275. doi:10.1038/nchembio.317. PMID 20228795.
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