Coproporphyrinogen dehydrogenase

coproporphyrinogen dehydrogenase
Identifiers
EC number	1.3.99.22
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a coproporphyrinogen dehydrogenase (EC 1.3.99.22) is an enzyme that catalyzes the chemical reaction

coproporphyrinogen III + 2 S-adenosyl-L-methionine $\rightleftharpoons$ protoporphyrinogen IX + 2 CO₂ + 2 L-methionine + 2 5'-deoxyadenosine

Thus, the two substrates of this enzyme are coproporphyrinogen III and S-adenosyl-L-methionine, whereas its 4 products are protoporphyrinogen IX, CO₂, L-methionine, and 5'-deoxyadenosine.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating). Other names in common use include oxygen-independent coproporphyrinogen-III oxidase, HemN, radical SAM enzyme, and coproporphyrinogen III oxidase. This enzyme participates in porphyrin and chlorophyll metabolism.

References

• Layer G, Verfurth K, Mahlitz E, Jahn D (2002). "Oxygen-independent coproporphyrinogen-III oxidase HemN from Escherichia coli". J. Biol. Chem. 277 (37): 34136–42. doi:10.1074/jbc.M205247200. PMID 12114526.
• Layer G, Moser J, Heinz DW, Jahn D, Schubert WD (2003). "Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes". EMBO J. 22 (23): 6214–24. doi:10.1093/emboj/cdg598. PMC 291839. PMID 14633981.