Crotonyl-CoA carboxylase/reductase

Crotonyl-CoA carboxylase/reductase (EC 1.3.1.85, CCR, crotonyl-CoA reductase (carboxylating)) is an enzyme with systematic name (2S)-ethylmalonyl-CoA:NADP⁺ oxidoreductase (decarboxylating).^[1]^[2] This enzyme catalyses the following chemical reaction

(2S)-ethylmalonyl-CoA + NADP⁺

\rightleftharpoons

(E)-but-2-enoyl-CoA + CO₂ + NADPH + H⁺

The reaction is catalysed in the reverse direction.

References

↑ Erb, T.J., Berg, I.A., Brecht, V., Muller, M., Fuchs, G. and Alber, B.E. (2007). "Synthesis of C₅-dicarboxylic acids from C₂-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway". Proc. Natl. Acad. Sci. USA 104: 10631–10636. doi:10.1073/pnas.0702791104. PMC 1965564. PMID 17548827.
↑ Erb, T.J., Brecht, V., Fuchs, G., Muller, M. and Alber, B.E. (2009). "Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase". Proc. Natl. Acad. Sci. USA 106: 8871–8876. doi:10.1073/pnas.0903939106. PMC 2689996. PMID 19458256.

External links

Crotonyl-CoA carboxylase/reductase at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: CH–CH oxidoreductases (EC 1.3)

1.3.1: NAD/NADP acceptor	Enoyl-acyl carrier protein reductase/Enoyl ACP reductase 7-Dehydrocholesterol reductase Biliverdin reductase 2,4 Dienoyl-CoA reductase Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase

1.3.3: Oxygen acceptor	Dihydroorotate dehydrogenase Coproporphyrinogen III oxidase Protoporphyrinogen oxidase Bilirubin oxidase Acyl-CoA oxidase Dihydrouracil oxidase Tetrahydroberberine oxidase Secologanin synthase Tryptophan alpha,beta-oxidase Pyrroloquinoline-quinone synthase L-galactonolactone oxidase

1.3.5: Quinone	Succinate dehydrogenase SDHA SDHB SDHC SDHD

1.3.99: Other acceptors	Fumarate reductase Butyryl-CoA dehydrogenase Acyl CoA dehydrogenase ACADSB ACADS 5α-reductase SRD5A1 SRD5A2 SRD5A3 Glutaryl-CoA dehydrogenase Isovaleryl coenzyme A dehydrogenase 3-oxo-5beta-steroid 4-dehydrogenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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