D-xylose reductase

D-xylose reductase
Identifiers
EC number 1.1.1.307
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

D-xylose reductase (EC 1.1.1.307, XylR, XyrA, msXR, dsXR, monospecific xylose reductase, dual specific xylose reductase, NAD(P)H-dependent xylose reductase, xylose reductase) is an enzyme with systematic name xylitol:NAD(P)+ oxidoreductase.[1][2][3][4][5][6][7][8] This enzyme catalyses the following chemical reaction

xylitol + NAD(P)+ \rightleftharpoons D-xylose + NAD(P)H + H+

Xylose reductase catalyses the initial reaction in the xylose utilization pathway, the NAD(P)H dependent reduction of xylose to xylitol.

References

  1. ↑ Neuhauser, W., Haltrich, D., Kulbe, K.D. and Nidetzky, B. (1997). "NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis. Isolation, characterization and biochemical properties of the enzyme". Biochem. J. 326 (Pt 3): 683–692. PMC 1218722. PMID 9307017.
  2. ↑ Nidetzky, B., Bruggler, K., Kratzer, R. and Mayr, P. (2003). "Multiple forms of xylose reductase in Candida intermedia: comparison of their functional properties using quantitative structure-activity relationships, steady-state kinetic analysis, and pH studies". J. Agric. Food Chem. 51 (27): 7930–7935. doi:10.1021/jf034426j. PMID 14690376.
  3. ↑ Iablochkova, E.N., Bolotnikova, O.I., Mikhailova, N.P., Nemova, N.N. and Ginak, A.I. (2003). "The activity of xylose reductase and xylitol dehydrogenase in yeasts". Mikrobiologiia 72 (4): 466–469. PMID 14526534.
  4. ↑ Chen, L.C., Huang, S.C., Chuankhayan, P., Chen, C.D., Huang, Y.C., Jeyakanthan, J., Pang, H.F., Men, L.C., Chen, Y.C., Wang, Y.K., Liu, M.Y., Wu, T.K. and Chen, C.J. (2009). "Purification, crystallization and preliminary X-ray crystallographic analysis of xylose reductase from Candida tropicalis". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 (Pt 4): 419–421. doi:10.1107/S1744309109008719. PMC 2664776. PMID 19342796.
  5. ↑ Verduyn, C., Van Kleef, R., Frank, J., Schreuder, H., Van Dijken, J.P. and Scheffers, W.A. (1985). "Properties of the NAD(P)H-dependent xylose reductase from the xylose-fermenting yeast Pichia stipitis". Biochem. J. 226 (3): 669–677. PMC 1144764. PMID 3921014.
  6. ↑ Fernandes, S., Tuohy, M.G. and Murray, P.G. (2009). "Xylose reductase from the thermophilic fungus Talaromyces emersonii: cloning and heterologous expression of the native gene (Texr) and a double mutant (TexrK271R + N273D) with altered coenzyme specificity". J. Biosci. 34 (6): 881–890. doi:10.1007/s12038-009-0102-7. PMID 20093741.
  7. ↑ Lee, J.K., Koo, B.S. and Kim, S.Y. (2003). "Cloning and characterization of the xyl1 gene, encoding an NADH-preferring xylose reductase from Candida parapsilosis, and its functional expression in Candida tropicalis". Appl. Environ. Microbiol. 69 (10): 6179–6188. doi:10.1128/AEM.69.10.6179-6188.2003. PMC 201247. PMID 14532079.
  8. ↑ Woodyer, R., Simurdiak, M., van der Donk, W.A. and Zhao, H. (2005). "Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa". Appl. Environ. Microbiol. 71 (3): 1642–1647. doi:10.1128/AEM.71.3.1642-1647.2005. PMC 1065158. PMID 15746370.

External links

This article is issued from Wikipedia - version of the Wednesday, March 30, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.