DAAM1

Dishevelled associated activator of morphogenesis 1
PDB rendering based on 2j1d.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2J1D​, 2Z6E​
Identifiers
Symbols	DAAM1 ; FLJ41657; KIAA0666
External IDs	OMIM: 606626 MGI: 1914596 HomoloGene: 36635 GeneCards: DAAM1 Gene
Gene ontology Molecular function • actin binding • protein binding • Rho GTPase binding • identical protein binding Cellular component • stress fiber • cytoplasm • cytosol • plasma membrane • membrane Biological process • small GTPase mediated signal transduction • actin cytoskeleton organization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23002	208846
Ensembl	ENSG00000100592	ENSMUSG00000034574
UniProt	Q9Y4D1	Q8BPM0
RefSeq (mRNA)	NM_001270520	NM_001286452
RefSeq (protein)	NP_001257449	NP_001273381
Location (UCSC)	Chr 14: 59.19 – 59.37 Mb	Chr 12: 71.83 – 71.99 Mb
PubMed search

Disheveled-associated activator of morphogenesis 1 is a protein that in humans is encoded by the DAAM1 gene.^[1][2][3] Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.

Function

Cell motility, adhesion, and cytokinesis, and other functions of the cell cortex are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein.^[3]

Clinical significance

The deletion of a single copy of this gene has been associated with congenital heart defects.^[4]

References

1. Habas R, Kato Y, He X (Jan 2002). "Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1". Cell 107 (7): 843–54. doi:10.1016/S0092-8674(01)00614-6. PMID 11779461.
2. Liu W, Sato A, Khadka D, Bharti R, Diaz H, Runnels LW, Habas R (Jan 2008). "Mechanism of activation of the Formin protein Daam1". Proc Natl Acad Sci U S A 105 (1): 210–5. doi:10.1073/pnas.0707277105. PMC 2224188. PMID 18162551.
3. "Entrez Gene: DAAM1 dishevelled associated activator of morphogenesis 1".
4. Bao B, Zhang L, Hu H, Yin S, Liang Z (August 2012). "Deletion of a single-copy DAAM1 gene in congenital heart defect: a case report". BMC Med. Genet. 13 (1): 63. doi:10.1186/1471-2350-13-63. PMC 3482563. PMID 22857009.

Further reading

• Tanaka K (2000). "Formin family proteins in cytoskeletal control.". Biochem. Biophys. Res. Commun. 267 (2): 479–81. doi:10.1006/bbrc.1999.1707. PMID 10631086.
• Ishikawa K, Nagase T, Suyama M; et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Heilig R, Eckenberg R, Petit JL; et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Aspenström P, Richnau N, Johansson AS (2006). "The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics.". Exp. Cell Res. 312 (12): 2180–94. doi:10.1016/j.yexcr.2006.03.013. PMID 16630611.
• Sato A, Khadka DK, Liu W; et al. (2007). "Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation.". Development 133 (21): 4219–31. doi:10.1242/dev.02590. PMID 17021034.
• Lu J, Meng W, Poy F; et al. (2007). "Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly.". J. Mol. Biol. 369 (5): 1258–69. doi:10.1016/j.jmb.2007.04.002. PMC 1939941. PMID 17482208.