Dishevelled

Dishevelled specific domain
Solution structure of the mouse Dvl-1 DEP domain based on the PDB: 1fsh​ coordinates.
Identifiers
Symbol	Dishevelled
Pfam	PF02377
InterPro	IPR003351
PROSITE	PDOC50841
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Dishevelled (Dsh) is a family of proteins involved in canonical and non-canonical Wnt signalling pathways. Dsh is a cytoplasmic phosphoprotein that acts directly downstream of frizzled receptors.^[1] It takes its name from its initial discovery in flies, where a mutation in the dishevelled gene was observed to cause improper orientation of body and wing hairs.^[2]

Dishevelled plays important roles in both the embryo and the adult, ranging from cellular differentiation and cell polarity to social behavior.^[2]

Members

There are three human genes that encode for the dishevelled proteins:^[3]

• DVL1
• DVL2
• DVL3

Overview of signal transduction pathways involved in apoptosis.

Example

Alignment of dishevelled-specific domain

References

1. Penton A, Wodarz A, Nusse R (June 2002). "A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin". Genetics 161 (2): 747–62. PMC 1462152. PMID 12072470.
2. Wallingford JB, Habas R (October 2005). "The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity". Development 132 (20): 4421–36. doi:10.1242/dev.02068. PMID 16192308.
3. Lee YN, Gao Y, Wang HY (February 2008). "Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3". Cell. Signal. 20 (2): 443–52. doi:10.1016/j.cellsig.2007.11.005. PMC 2233603. PMID 18093802.

External links

• dishevelled proteins at the US National Library of Medicine Medical Subject Headings (MeSH)