WNT11

Wingless-type MMTV integration site family, member 11
Identifiers
Symbols	WNT11 ; HWNT11
External IDs	OMIM: 603699 MGI: 101948 HomoloGene: 20970 GeneCards: WNT11 Gene
Gene ontology Molecular function • GTPase activator activity • frizzled binding • protein binding • protein kinase activator activity • transcription regulatory region DNA binding Cellular component • extracellular region • proteinaceous extracellular matrix • extracellular space • cytoplasm Biological process • osteoblast differentiation • outflow tract morphogenesis • protein phosphorylation • positive regulation of gene expression • Wnt signaling pathway • neuron differentiation • bone mineralization • negative regulation of cell growth • adrenal gland development • positive regulation of cell migration • negative regulation of cell migration • response to nutrient levels • activation of protein kinase activity • positive regulation of transforming growth factor beta2 production • protein localization to cell surface • non-canonical Wnt signaling pathway • positive regulation of apoptotic process • negative regulation of apoptotic process • positive regulation of GTPase activity • cell fate commitment • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • embryonic skeletal system development • artery morphogenesis • positive regulation of stress fiber assembly • palate development • canonical Wnt signaling pathway • cloacal septation • ventricular septum morphogenesis • lung-associated mesenchyme development • negative regulation of cell death • ureteric bud morphogenesis • negative regulation of cartilage development • neuroendocrine cell differentiation • bicellular tight junction assembly • cellular response to retinoic acid • mesonephric duct development • negative regulation of mesenchymal cell proliferation • positive regulation of protein kinase C signaling • negative regulation of canonical Wnt signaling pathway • negative regulation of fibroblast growth factor production Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7481	22411
Ensembl	ENSG00000085741	ENSMUSG00000015957
UniProt	O96014	P48615
RefSeq (mRNA)	NM_004626	NM_001285792
RefSeq (protein)	NP_004617	NP_001272721
Location (UCSC)	Chr 11: 76.19 – 76.21 Mb	Chr 7: 98.84 – 98.86 Mb
PubMed search

Protein Wnt-11 is a protein that in humans is encoded by the WNT11 gene.^[1][2]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney, and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome.^[2]

References

1. Lako M, Strachan T, Bullen P, Wilson DI, Robson SC, Lindsay S (Dec 1998). "Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung". Gene 219 (1–2): 101–10. doi:10.1016/S0378-1119(98)00393-X. PMID 9757009.
2. "Entrez Gene: WNT11 wingless-type MMTV integration site family, member 11".

Further reading

• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell 4 (12): 1267–75. doi:10.1051/jp3:1994201. PMC 275763. PMID 8167409.
• Kirikoshi H, Sekihara H, Katoh M (2002). "Molecular cloning and characterization of human WNT11". Int. J. Mol. Med. 8 (6): 651–6. doi:10.3892/ijmm.8.6.651. PMID 11712081.
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ouko L; Ziegler TR; Gu LH; et al. (2004). "Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells". J. Biol. Chem. 279 (25): 26707–15. doi:10.1074/jbc.M402877200. PMC 1351009. PMID 15084607.
• Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim SW; Park JI; Spring CM; et al. (2005). "Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin". Nat. Cell Biol. 6 (12): 1212–20. doi:10.1038/ncb1191. PMID 15543138.
• Koyanagi M; Haendeler J; Badorff C; et al. (2005). "Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells". J. Biol. Chem. 280 (17): 16838–42. doi:10.1074/jbc.M500323200. PMID 15701629.
• Garriock RJ, D'Agostino SL, Pilcher KC, Krieg PA (2005). "Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus". Dev. Biol. 279 (1): 179–92. doi:10.1016/j.ydbio.2004.12.013. PMID 15708567.
• Otsuki T; Ota T; Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Panáková D, Werdich AA, Macrae CA (2010). "Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel.". Nature 466 (8): 874–878. doi:10.1038/nature09249. PMC 2921013. PMID 20657579.