WNT10B

Wingless-type MMTV integration site family, member 10B
Identifiers
Symbols	WNT10B ; SHFM6; WNT-12
External IDs	OMIM: 601906 MGI: 108061 HomoloGene: 20721 GeneCards: WNT10B Gene
Gene ontology Molecular function • frizzled binding • receptor agonist activity Cellular component • extracellular region • proteinaceous extracellular matrix • extracellular space Biological process • G2/M transition of mitotic cell cycle • negative regulation of transcription from RNA polymerase II promoter • chondrocyte differentiation • lipid metabolic process • cell cycle arrest • smoothened signaling pathway • positive regulation of cell proliferation • positive regulation of G2/M transition of mitotic cell cycle • myoblast differentiation involved in skeletal muscle regeneration • Wnt signaling pathway • neuron differentiation • positive regulation of bone mineralization • positive regulation of epithelial cell differentiation • regulation of proteasomal ubiquitin-dependent protein catabolic process • positive regulation of apoptotic process • cell fate commitment • negative regulation of fat cell differentiation • positive regulation of osteoblast differentiation • positive regulation of RNA polymerase II transcriptional preinitiation complex assembly • regulation of skeletal muscle tissue development • skeletal muscle fiber development • negative regulation of epithelial cell proliferation • protein stabilization • sensory perception of taste • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of anagen • canonical Wnt signaling pathway • bone trabecula formation • fungiform papilla development • cellular response to retinoic acid • cellular response to cAMP • cellular response to parathyroid hormone stimulus • hematopoietic stem cell proliferation • positive regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7480	22410
Ensembl	ENSG00000169884	ENSMUSG00000022996
UniProt	O00744	P48614
RefSeq (mRNA)	NM_003394	NM_011718
RefSeq (protein)	NP_003385	NP_035848
Location (UCSC)	Chr 12: 48.97 – 48.97 Mb	Chr 15: 98.77 – 98.78 Mb
PubMed search

Protein Wnt-10b (formerly Wnt12^[1]) is a protein that in humans is encoded by the WNT10B gene.^[2][3][4][5]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is, it is presumed, a molecular switch that governs adipogenesis. Gain-of-function of Wnt10b in mouse hearts has shown to improve cardiac tissue repair after myocardial injury, by promoting coronary vessel formation and attenuating pathological fibrosis.^[6] This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.^[5]

References

1. Schubert M, Holland LZ, Holland ND, Jacobs DK (2000). "A phylogenetic tree of the Wnt genes based on all available full-length sequences, including five from the cephalochordate amphioxus". Molecular Biology and Evolution 17 (12): 1896–903. doi:10.1093/oxfordjournals.molbev.a026291. PMID 11110906.
2. Bui TD, Rankin J, Smith K, Huguet EL, Ruben S, Strachan T, Harris AL, Lindsay S (Apr 1997). "A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas". Oncogene 14 (10): 1249–53. doi:10.1038/sj.onc.1200936. PMID 9121776.
3. Hardiman G, Kastelein RA, Bazan JF (Sep 1997). "Isolation, characterization and chromosomal localization of human WNT10B". Cytogenet Cell Genet 77 (3–4): 278–82. doi:10.1159/000134597. PMID 9284937.
4. Ugur SA, Tolun A (Aug 2008). "Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation". Hum Mol Genet 17 (17): 2644–53. doi:10.1093/hmg/ddn164. PMID 18515319.
5. "Entrez Gene: WNT10B wingless-type MMTV integration site family, member 10B".
6. Paik DT, Rai M, Ryzhov S, Sanders LN, Aisagbonhi O, Funke MJ, Feoktistov I, Hatzopoulos AK. Wnt10b gain-of-function improves cardiac repair by arteriole formation and attenuation of fibrosis. Circ Res. 2015; 117:804-816.

Further reading

• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell 4 (12): 1267–75. doi:10.1051/jp3:1994201. PMC 275763. PMID 8167409.
• Bergstein I, Eisenberg LM, Bhalerao J, et al. (1998). "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21". Genomics 46 (3): 450–8. doi:10.1006/geno.1997.5041. PMID 9441749.
• Ross SE, Hemati N, Longo KA, et al. (2000). "Inhibition of adipogenesis by Wnt signaling". Science 289 (5481): 950–3. doi:10.1126/science.289.5481.950. PMID 10937998.
• Kirikoshi H, Sekihara H, Katoh M (2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells". Biochem. Biophys. Res. Commun. 283 (4): 798–805. doi:10.1006/bbrc.2001.4855. PMID 11350055.
• Saitoh T, Kirikoshi H, Mine T, Katoh M (2002). "Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45". Int. J. Oncol. 19 (6): 1187–92. doi:10.3892/ijo.19.6.1187. PMID 11713588.
• Kasat K, Go V, Pogo BG (2003). "Effects of pyrethroid insecticides and estrogen on WNT10B proto-oncogene expression". Environment international 28 (5): 429–32. doi:10.1016/S0160-4120(02)00072-7. PMID 12437293.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Christodoulides C, Scarda A, Granzotto M, et al. (2006). "WNT10B mutations in human obesity". Diabetologia 49 (4): 678–84. doi:10.1007/s00125-006-0144-4. PMID 16477437.
• Thrasivoulou, C, Millar, M and Ahmed, A (2013). "Activation of intracellular calcium by multiple Wnt ligands and translocation of ß-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/ß-catenin pathways". J. Biol. Chem. 288 (50): 35651–35659. doi:10.1074/jbc.M112.437913. PMID 24158438.