WNT3

Wingless-type MMTV integration site family, member 3
Identifiers
Symbols	WNT3 ; INT4; TETAMS
External IDs	OMIM: 165330 MGI: 98955 HomoloGene: 22527 ChEMBL: 6079 GeneCards: WNT3 Gene
Gene ontology Molecular function • frizzled binding • protein binding • protein domain specific binding • receptor agonist activity Cellular component • extracellular region • proteinaceous extracellular matrix • extracellular space • endoplasmic reticulum lumen • Golgi lumen • plasma membrane Biological process • cell morphogenesis • mesoderm formation • gamete generation • axon guidance • anterior/posterior axis specification • dorsal/ventral axis specification • positive regulation of gene expression • positive regulation of Wnt signaling pathway • neuron differentiation • embryonic forelimb morphogenesis • embryonic hindlimb morphogenesis • canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation • canonical Wnt signaling pathway involved in osteoblast differentiation • cell fate commitment • positive regulation of collateral sprouting in absence of injury • negative regulation of axon extension involved in axon guidance • Spemann organizer formation at the anterior end of the primitive streak • canonical Wnt signaling pathway • limb bud formation • head morphogenesis • mammary gland epithelium development • cellular response to retinoic acid Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7473	22415
Ensembl	ENSG00000108379	ENSMUSG00000000125
UniProt	P56703	P17553
RefSeq (mRNA)	NM_030753	NM_009521
RefSeq (protein)	NP_110380	NP_033547
Location (UCSC)	Chr 17: 46.76 – 46.83 Mb	Chr 11: 103.77 – 103.82 Mb
PubMed search

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.^[1][2]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.^[2]

References

1. Roelink H, Wang J, Black DM, Solomon E, Nusse R (Dec 1993). "Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene". Genomics 17 (3): 790–2. doi:10.1006/geno.1993.1412. PMID 8244403.
2. "Entrez Gene: WNT3 wingless-type MMTV integration site family, member 3".

External links

• GeneReviews/NIH/NCBI/UW entry on Tetra-Amelia Syndrome

Further reading

• Nusse R, Brown A, Papkoff J, et al. (1991). "A new nomenclature for int-1 and related genes: the Wnt gene family". Cell 64 (2): 231. doi:10.1016/0092-8674(91)90633-A. PMID 1846319.
• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell 4 (12): 1267–75. doi:10.1051/jp3:1994201. PMC 275763. PMID 8167409.
• Liu P, Wakamiya M, Shea MJ, et al. (1999). "Requirement for Wnt3 in vertebrate axis formation". Nat. Genet. 22 (4): 361–5. doi:10.1038/11932. PMID 10431240.
• Gazit A, Yaniv A, Bafico A, et al. (1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response". Oncogene 18 (44): 5959–66. doi:10.1038/sj.onc.1202985. PMID 10557084.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Katoh M (2002). "Molecular cloning and characterization of human WNT3". Int. J. Oncol. 19 (5): 977–82. doi:10.3892/ijo.19.5.977. PMID 11604997.
• Katoh M (2002). "Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45". Int. J. Oncol. 20 (2): 373–7. doi:10.3892/ijo.20.2.373. PMID 11788904.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Niemann S, Zhao C, Pascu F, et al. (2004). "Homozygous WNT3 Mutation Causes Tetra-Amelia in a Large Consanguineous Family". Am. J. Hum. Genet. 74 (3): 558–63. doi:10.1086/382196. PMC 1182269. PMID 14872406.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chiba H, Kobune M, Kato J, et al. (2005). "Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells". Exp. Hematol. 32 (12): 1194–203. doi:10.1016/j.exphem.2004.08.010. PMID 15588944.
• Yamamoto H, Komekado H, Kikuchi A (2006). "Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin". Dev. Cell 11 (2): 213–23. doi:10.1016/j.devcel.2006.07.003. PMID 16890161.