WNT7B

Wingless-type MMTV integration site family, member 7B
Identifiers
Symbol	WNT7B
External IDs	OMIM: 601967 MGI: 98962 HomoloGene: 22531 GeneCards: WNT7B Gene
Gene ontology Molecular function • frizzled binding Cellular component • extracellular region • proteinaceous extracellular matrix • extracellular space • endoplasmic reticulum lumen • Golgi lumen • plasma membrane Biological process • in utero embryonic development • metanephros morphogenesis • positive regulation of cell proliferation • positive regulation of gene expression • Wnt signaling pathway • establishment or maintenance of polarity of embryonic epithelium • forebrain regionalization • central nervous system vasculogenesis • neuron differentiation • lung development • oxygen homeostasis • odontogenesis of dentin-containing tooth • homeostatic process • cellular metabolic process • cell fate commitment • positive regulation of osteoblast differentiation • negative regulation of smoothened signaling pathway • positive regulation of JNK cascade • fibroblast proliferation • embryonic organ development • synapse organization • smooth muscle cell differentiation • anatomical structure regression • canonical Wnt signaling pathway • lung morphogenesis • lung epithelium development • lobar bronchus development • lung-associated mesenchyme development • trachea cartilage morphogenesis • developmental growth involved in morphogenesis • embryonic placenta morphogenesis • chorio-allantoic fusion • mammary gland epithelium development • lens fiber cell development • cellular response to retinoic acid • renal inner medulla development • renal outer medulla development • outer medullary collecting duct development • inner medullary collecting duct development • stem cell proliferation • metanephric collecting duct development • metanephric epithelium development • metanephric loop of Henle development • apoptotic process involved in patterning of blood vessels Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7477	22422
Ensembl	ENSG00000188064	ENSMUSG00000022382
UniProt	P56706	P28047
RefSeq (mRNA)	NM_058238	NM_001163633
RefSeq (protein)	NP_478679	NP_001157105
Location (UCSC)	Chr 22: 45.92 – 45.98 Mb	Chr 15: 85.54 – 85.58 Mb
PubMed search

Protein Wnt-7b is a protein that in humans is encoded by the WNT7B gene.^[1][2][3][4]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 99% and 91% amino acid identity to the mouse and Xenopus Wnt7A proteins, respectively. Among members of the human WNT family, this protein is most similar to WNT7A protein (77.1% total amino acid identity). This gene may play important roles in the development and progression of gastric cancer, esophageal cancer, and pancreatic cancer.^[4]

References

1. Huguet EL, McMahon JA, McMahon AP, Bicknell R, Harris AL (Jun 1994). "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue". Cancer Res 54 (10): 2615–21. PMID 8168088.
2. van Bokhoven H, Kissing J, Schepens M, van Beersum S, Simons A, Riegman P, McMahon JA, McMahon AP, Brunner HG (Sep 1997). "Assignment of WNT7B to human chromosome band 22q13 by in situ hybridization". Cytogenet Cell Genet 77 (3–4): 288–9. doi:10.1159/000134600. PMID 9284940.
3. Kirikoshi H, Sekihara H, Katoh M (Sep 2001). "Molecular cloning and characterization of human WNT7B". Int J Oncol 19 (4): 779–83. doi:10.3892/ijo.19.4.779. PMID 11562755.
4. "Entrez Gene: WNT7B wingless-type MMTV integration site family, member 7B".

Further reading

• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell 4 (12): 1267–75. doi:10.1051/jp3:1994201. PMC 275763. PMID 8167409.
• Tanaka K, Okabayashi K, Asashima M, et al. (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". Eur. J. Biochem. 267 (13): 4300–11. doi:10.1046/j.1432-1033.2000.01478.x. PMID 10866835.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Capurro MI, Shi W, Sandal S, Filmus J (2006). "Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth". J. Biol. Chem. 280 (50): 41201–6. doi:10.1074/jbc.M507004200. PMID 16227623.