WNT3A

Wingless-type MMTV integration site family, member 3A
Identifiers
Symbols	WNT3A ; MGC119418; MGC119419; MGC119420
External IDs	OMIM: 606359 MGI: 98956 HomoloGene: 22528 ChEMBL: 1255137 GeneCards: WNT3A Gene
Gene ontology Molecular function • transcription coactivator activity • frizzled binding • frizzled-2 binding • protein binding • protein domain specific binding • receptor agonist activity Cellular component • extracellular region • proteinaceous extracellular matrix • extracellular space • endoplasmic reticulum lumen • Golgi lumen • plasma membrane • cell surface • early endosome membrane Biological process • osteoblast differentiation • in utero embryonic development • positive regulation of cytokine production • positive regulation of protein phosphorylation • heart looping • positive regulation of receptor internalization • negative regulation of heart induction by canonical Wnt signaling pathway • axon guidance • positive regulation of cell proliferation • COP9 signalosome assembly • negative regulation of neuron projection development • spinal cord association neuron differentiation • hippocampus development • cell proliferation in forebrain • Wnt signaling pathway involved in forebrain neuroblast division • dorsal/ventral neural tube patterning • hemopoiesis • neuron differentiation • extracellular matrix organization • mammary gland development • positive regulation of B cell proliferation • positive regulation of protein binding • positive regulation of peptidyl-serine phosphorylation • cellular protein localization • positive regulation of catenin import into nucleus • skeletal muscle cell differentiation • post-anal tail morphogenesis • inner ear morphogenesis • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • cell fate commitment • negative regulation of fat cell differentiation • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of mesodermal cell fate specification • paraxial mesodermal cell fate commitment • positive regulation of skeletal muscle tissue development • positive regulation of collateral sprouting in absence of injury • negative regulation of axon extension involved in axon guidance • negative regulation of neurogenesis • positive regulation of sequence-specific DNA binding transcription factor activity • palate development • canonical Wnt signaling pathway • positive regulation of protein tyrosine kinase activity • positive regulation of dermatome development • canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment • regulation of microtubule cytoskeleton organization • platelet aggregation • cellular response to retinoic acid • negative regulation of canonical Wnt signaling pathway • axis elongation involved in somitogenesis • positive regulation of canonical Wnt signaling pathway • positive regulation of cell-cell adhesion mediated by cadherin • positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation • positive regulation of neural precursor cell proliferation • positive regulation of cardiac muscle cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	89780	22416
Ensembl	ENSG00000154342	ENSMUSG00000009900
UniProt	P56704	P27467
RefSeq (mRNA)	NM_033131	NM_009522
RefSeq (protein)	NP_149122	NP_033548
Location (UCSC)	Chr 1: 228.01 – 228.06 Mb	Chr 11: 59.25 – 59.29 Mb
PubMed search

Protein Wnt-3a is a protein that in humans is encoded by the WNT3A gene.^[1][2]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis, adipogenesis etc^[3] and in several other developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.^[2]

References

1. Saitoh T, Hirai M, Katoh M (Jun 2001). "Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region". Biochem Biophys Res Commun 284 (5): 1168–75. doi:10.1006/bbrc.2001.5105. PMID 11414706.
2. "Entrez Gene: WNT3A wingless-type MMTV integration site family, member 3A".
3. http://www.jbc.org/content/280/25/24004.full

Further reading

• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface.". Mol. Biol. Cell 4 (12): 1267–75. doi:10.1051/jp3:1994201. PMC 275763. PMID 8167409.
• Huguet EL, McMahon JA, McMahon AP, et al. (1994). "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue.". Cancer Res. 54 (10): 2615–21. PMID 8168088.
• Gazit A, Yaniv A, Bafico A, et al. (1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.". Oncogene 18 (44): 5959–66. doi:10.1038/sj.onc.1202985. PMID 10557084.
• Tanaka K, Okabayashi K, Asashima M, et al. (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.". Eur. J. Biochem. 267 (13): 4300–11. doi:10.1046/j.1432-1033.2000.01478.x. PMID 10866835.
• Katoh M (2002). "Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45.". Int. J. Oncol. 20 (2): 373–7. doi:10.3892/ijo.20.2.373. PMID 11788904.
• Katoh M (2002). "Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster.". Int. J. Mol. Med. 9 (3): 221–7. doi:10.3892/ijmm.9.3.221. PMID 11836627.
• Filali M, Cheng N, Abbott D, et al. (2002). "Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter.". J. Biol. Chem. 277 (36): 33398–410. doi:10.1074/jbc.M107977200. PMID 12052822.
• Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.". FEBS Lett. 521 (1-3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hino S, Michiue T, Asashima M, Kikuchi A (2003). "Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin.". J. Biol. Chem. 278 (16): 14066–73. doi:10.1074/jbc.M213265200. PMID 12556519.
• Qiang YW, Endo Y, Rubin JS, Rudikoff S (2003). "Wnt signaling in B-cell neoplasia.". Oncogene 22 (10): 1536–45. doi:10.1038/sj.onc.1206239. PMID 12629517.
• Hocevar BA, Mou F, Rennolds JL, et al. (2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2).". EMBO J. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. PMC 162138. PMID 12805222.
• Liu G, Bafico A, Harris VK, Aaronson SA (2003). "A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.". Mol. Cell. Biol. 23 (16): 5825–35. doi:10.1128/MCB.23.16.5825-5835.2003. PMC 166321. PMID 12897152.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Swiatek W, Tsai IC, Klimowski L, et al. (2004). "Regulation of casein kinase I epsilon activity by Wnt signaling.". J. Biol. Chem. 279 (13): 13011–7. doi:10.1074/jbc.M304682200. PMID 14722104.
• Zilberberg A, Yaniv A, Gazit A (2004). "The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway.". J. Biol. Chem. 279 (17): 17535–42. doi:10.1074/jbc.M311292200. PMID 14739301.
• Lu W, Yamamoto V, Ortega B, Baltimore D (2004). "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.". Cell 119 (1): 97–108. doi:10.1016/j.cell.2004.09.019. PMID 15454084.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Capurro MI, Shi W, Sandal S, Filmus J (2006). "Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth.". J. Biol. Chem. 280 (50): 41201–6. doi:10.1074/jbc.M507004200. PMID 16227623.
• Thrasivoulou, C, Millar, M and Ahmed, A (2013). "Activation of intracellular calcium by multiple Wnt ligands and translocation of ß-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/ß-catenin pathways". J. Biol. Chem. 288 (50): 35651–35659. doi:10.1074/jbc.M112.437913. PMID 24158438.