WNT2B

Wingless-type MMTV integration site family, member 2B
Identifiers
Symbols	WNT2B ; WNT13
External IDs	OMIM: 601968 MGI: 1261834 HomoloGene: 22526 GeneCards: WNT2B Gene
Gene ontology Molecular function • frizzled binding Cellular component • extracellular region • proteinaceous extracellular matrix • extracellular space Biological process • chondrocyte differentiation • lens development in camera-type eye • male gonad development • cellular response to starvation • Wnt signaling pathway • forebrain regionalization • neuron differentiation • cell fate commitment • canonical Wnt signaling pathway • lung induction • mesenchymal-epithelial cell signaling • iris morphogenesis • cornea development in camera-type eye • hematopoietic stem cell proliferation • positive regulation of branching involved in ureteric bud morphogenesis • positive regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7482	22414
Ensembl	ENSG00000134245	ENSMUSG00000027840
UniProt	Q93097	O70283
RefSeq (mRNA)	NM_001291880	NM_009520
RefSeq (protein)	NP_001278809	NP_033546
Location (UCSC)	Chr 1: 112.47 – 112.53 Mb	Chr 3: 104.95 – 104.96 Mb
PubMed search

Protein Wnt-2b (formerly Wnt13^[1]) is a protein that in humans is encoded by the WNT2B gene.^[2][3][4]

This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis.

This gene produces two alternative transcript variants.^[4]

References

1. Kubo F, Takeichi M, Nakagawa S (2003). "Wnt2b controls retinal cell differentiation at the ciliary marginal zone". Development (Cambridge, England) 130 (3): 587–98. PMID 12490564.
2. Katoh M, Hirai M, Sugimura T, Terada M (Oct 1996). "Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family". Oncogene 13 (4): 873–6. PMID 8761309.
3. Katoh M, Kirikoshi H, Saitoh T, Sagara N, Koike J (Sep 2000). "Alternative splicing of the WNT-2B/WNT-13 gene". Biochem Biophys Res Commun 275 (1): 209–16. doi:10.1006/bbrc.2000.3252. PMID 10944466.
4. "Entrez Gene: WNT2B wingless-type MMTV integration site family, member 2B".

Further reading

• Katoh M (2006). "WNT2B: comparative integromics and clinical applications (Review).". Int. J. Mol. Med. 16 (6): 1103–8. doi:10.3892/ijmm.16.6.1103. PMID 16273293.
• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface.". Mol. Biol. Cell 4 (12): 1267–75. doi:10.1051/jp3:1994201. PMC 275763. PMID 8167409.
• Bergstein I, Eisenberg LM, Bhalerao J, et al. (1998). "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21.". Genomics 46 (3): 450–8. doi:10.1006/geno.1997.5041. PMID 9441749.
• Katoh M (2002). "Differential regulation of WNT2 and WNT2B expression in human cancer.". Int. J. Mol. Med. 8 (6): 657–60. doi:10.3892/ijmm.8.6.657. PMID 11712082.
• Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening.". J. Cell. Biochem. 83 (4): 521–31. doi:10.1002/jcb.1257. PMID 11746496.
• Ricken A, Lochhead P, Kontogiannea M, Farookhi R (2002). "Wnt signaling in the ovary: identification and compartmentalized expression of wnt-2, wnt-2b, and frizzled-4 mRNAs.". Endocrinology 143 (7): 2741–9. doi:10.1210/en.143.7.2741. PMID 12072409.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Katoh M (2005). "Molecular evolution of Wnt2b orthologs.". Int. J. Oncol. 26 (4): 1135–9. doi:10.3892/ijo.26.4.1135. PMID 15754012.
• Struewing IT, Toborek A, Mao CD (2006). "Mitochondrial and nuclear forms of Wnt13 are generated via alternative promoters, alternative RNA splicing, and alternative translation start sites.". J. Biol. Chem. 281 (11): 7282–93. doi:10.1074/jbc.M511182200. PMID 16407296.