WNT9A

Wingless-type MMTV integration site family, member 9A
Identifiers
Symbols	WNT9A ; WNT14
External IDs	OMIM: 602863 MGI: 2446084 HomoloGene: 20722 GeneCards: WNT9A Gene
Gene ontology Molecular function • frizzled binding Cellular component • extracellular region • proteinaceous extracellular matrix • extracellular space • extracellular exosome Biological process • mitotic cell cycle checkpoint • cell-cell signaling • multicellular organismal development • negative regulation of cell proliferation • Wnt signaling pathway • neuron differentiation • negative regulation of chondrocyte differentiation • embryonic forelimb morphogenesis • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • cell fate commitment • positive regulation of cell differentiation • positive regulation of smoothened signaling pathway • embryonic skeletal system morphogenesis • canonical Wnt signaling pathway • iris morphogenesis • cornea development in camera-type eye • cellular response to retinoic acid • embryonic skeletal joint development • negative regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7483	216795
Ensembl	ENSG00000143816	ENSMUSG00000000126
UniProt	O14904	Q8R5M2
RefSeq (mRNA)	NM_003395	NM_139298
RefSeq (protein)	NP_003386	NP_647459
Location (UCSC)	Chr 1: 227.92 – 227.95 Mb	Chr 11: 59.31 – 59.33 Mb
PubMed search

Protein Wnt-9a (formerly Wnt14^[1]) is a protein that in humans is encoded by the WNT9A gene.^[2][3]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region.^[3]

References

1. Person AD, Garriock RJ, Krieg PA, Runyan RB, Klewer SE (2005). "Frzb modulates Wnt-9a-mediated beta-catenin signaling during avian atrioventricular cardiac cushion development". Developmental Biology 278 (1): 35–48. doi:10.1016/j.ydbio.2004.10.013. PMID 15649459.
2. Bergstein I, Eisenberg LM, Bhalerao J, Jenkins NA, Copeland NG, Osborne MP, Bowcock AM, Brown AM (Mar 1998). "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21". Genomics 46 (3): 450–8. doi:10.1006/geno.1997.5041. PMID 9441749.
3. "Entrez Gene: WNT9A wingless-type MMTV integration site family, member 9A".

Further reading

• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell 4 (12): 1267–75. doi:10.1051/jp3:1994201. PMC 275763. PMID 8167409.
• Hartmann C, Tabin CJ (2001). "Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton". Cell 104 (3): 341–51. doi:10.1016/S0092-8674(01)00222-7. PMID 11239392.
• Saitoh T, Hirai M, Katoh M (2001). "Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region". Biochem. Biophys. Res. Commun. 284 (5): 1168–75. doi:10.1006/bbrc.2001.5105. PMID 11414706.
• Katoh M (2002). "Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster". Int. J. Mol. Med. 9 (3): 221–7. doi:10.3892/ijmm.9.3.221. PMID 11836627.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Qian J, Jiang Z, Li M, et al. (2003). "Mouse Wnt9b transforming activity, tissue-specific expression, and evolution". Genomics 81 (1): 34–46. doi:10.1016/S0888-7543(02)00012-5. PMID 12573259.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Katoh Y, Katoh M (2005). "Comparative genomics on Wnt9a orthologs". Oncol. Rep. 13 (5): 989–92. doi:10.3892/or.13.5.989. PMID 15809769.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Bhattacharyya S, Borthakur A, Dudeja PK, Tobacman JK (2007). "Carrageenan reduces bone morphogenetic protein-4 (BMP4) and activates the Wnt/beta-catenin pathway in normal human colonocytes". Dig. Dis. Sci. 52 (10): 2766–74. doi:10.1007/s10620-006-9531-4. PMID 17429723.