DVL2

Dishevelled segment polarity protein 2
PDB rendering based on 1l6o.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2REY​, 3CBX​, 3CBY​, 3CBZ​, 3CC0​, 4WIP​
Identifiers
Symbol	DVL2
External IDs	OMIM: 602151 MGI: 106613 HomoloGene: 20927 ChEMBL: 1255125 GeneCards: DVL2 Gene
Gene ontology Molecular function • frizzled binding • protein binding • protein domain specific binding • identical protein binding • protein self-association Cellular component • nucleus • cytoplasm • cytosol • plasma membrane • cytoplasmic vesicle • apical part of cell • clathrin-coated endocytic vesicle Biological process • neural tube closure • positive regulation of protein phosphorylation • outflow tract morphogenesis • transcription from RNA polymerase II promoter • small GTPase mediated signal transduction • segment specification • heart development • Wnt signaling pathway • convergent extension involved in neural plate elongation • cellular protein localization • hippo signaling • non-canonical Wnt signaling pathway • positive regulation of JUN kinase activity • canonical Wnt signaling pathway involved in regulation of cell proliferation • positive regulation of transcription, DNA-templated • positive regulation of sequence-specific DNA binding transcription factor activity • canonical Wnt signaling pathway • Wnt signaling pathway, planar cell polarity pathway • positive regulation of protein tyrosine kinase activity • negative regulation of canonical Wnt signaling pathway • cochlea morphogenesis • planar cell polarity pathway involved in neural tube closure • positive regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1856	13543
Ensembl	ENSG00000004975	ENSMUSG00000020888
UniProt	O14641	Q60838
RefSeq (mRNA)	NM_004422	NM_007888
RefSeq (protein)	NP_004413	NP_031914
Location (UCSC)	Chr 17: 7.23 – 7.23 Mb	Chr 11: 70 – 70.01 Mb
PubMed search

Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene.^[1][2]

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.^[2]

Interactions

DVL2 has been shown to interact with Zinc finger protein 165,^[3] DAB2^[4] and Arrestin beta 1.^[5]

See also

• Dishevelled

References

1. Greco TL, Sussman DJ, Camper SA (January 1997). "Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11". Mamm Genome 7 (6): 475–6. doi:10.1007/s003359900144. PMID 8662242.
2. "Entrez Gene: DVL2 dishevelled, dsh homolog 2 (Drosophila)".
3. Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
4. Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. (England) 22 (12): 3084–94. doi:10.1093/emboj/cdg286. ISSN 0261-4189. PMC 162138. PMID 12805222.
5. Chen, W; Hu L A; Semenov M V; Yanagawa S; Kikuchi A; Lefkowitz R J; Miller W E (December 2001). "β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (26): 14889–94. doi:10.1073/pnas.211572798. ISSN 0027-8424. PMC 64954. PMID 11742073.

Further reading

• Pizzuti A, Amati F, Calabrese G; et al. (1997). "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene". Hum. Mol. Genet. 5 (7): 953–8. doi:10.1093/hmg/5.7.953. PMID 8817329.
• Klingensmith J, Yang Y, Axelrod JD; et al. (1997). "Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2". Mech. Dev. 58 (1–2): 15–26. doi:10.1016/S0925-4773(96)00549-7. PMID 8887313.
• Semënov MV, Snyder M (1997). "Human dishevelled genes constitute a DHR-containing multigene family". Genomics 42 (2): 302–10. doi:10.1006/geno.1997.4713. PMID 9192851.
• Strovel ET, Wu D, Sussman DJ (2000). "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription". J. Biol. Chem. 275 (4): 2399–403. doi:10.1074/jbc.275.4.2399. PMID 10644691.
• Song DH, Sussman DJ, Seldin DC (2000). "Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells". J. Biol. Chem. 275 (31): 23790–7. doi:10.1074/jbc.M909107199. PMID 10806215.
• Zhang Y, Neo SY, Han J, Lin SC (2000). "Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase". J. Biol. Chem. 275 (32): 25008–14. doi:10.1074/jbc.M002491200. PMID 10829020.
• Chen W, Hu LA, Semenov MV; et al. (2002). "β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 14889–94. doi:10.1073/pnas.211572798. PMC 64954. PMID 11742073.
• Habas R, Kato Y, He X (2002). "Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1". Cell 107 (7): 843–54. doi:10.1016/S0092-8674(01)00614-6. PMID 11779461.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Habas R, Dawid IB, He X (2003). "Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation". Genes Dev. 17 (2): 295–309. doi:10.1101/gad.1022203. PMC 195976. PMID 12533515.
• Chen W, ten Berge D, Brown J; et al. (2003). "Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4". Science 301 (5638): 1391–4. doi:10.1126/science.1082808. PMID 12958364.
• Wong CK, Luo W, Deng Y; et al. (2004). "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms". J. Biol. Chem. 279 (38): 39366–73. doi:10.1074/jbc.M404598200. PMID 15262978.
• Torban E, Wang HJ, Groulx N, Gros P (2005). "Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family". J. Biol. Chem. 279 (50): 52703–13. doi:10.1074/jbc.M408675200. PMID 15456783.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Zhang L, Gao X, Wen J; et al. (2006). "Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation". J. Biol. Chem. 281 (13): 8607–12. doi:10.1074/jbc.M600274200. PMID 16446366.
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.