DBF4
| DBF4 zinc finger | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| Identifiers | |||||||||||||
| Symbols | DBF4 ; ASK; CHIF; DBF4A; ZDBF1 | ||||||||||||
| External IDs | OMIM: 604281 MGI: 1351328 HomoloGene: 40892 ChEMBL: 4483 GeneCards: DBF4 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10926 | 27214 | |||||||||||
| Ensembl | ENSG00000006634 | ENSMUSG00000002297 | |||||||||||
| UniProt | Q9UBU7 | Q9QZ41 | |||||||||||
| RefSeq (mRNA) | NM_006716 | NM_001190717 | |||||||||||
| RefSeq (protein) | NP_006707 | NP_001177646 | |||||||||||
| Location (UCSC) |
Chr 7: 87.88 – 87.91 Mb |
Chr 5: 8.4 – 8.42 Mb | |||||||||||
| PubMed search | |||||||||||||
Protein DBF4 homolog A is a protein that is encoded by the DBF4 gene in humans.[1][2][3]
Interactions
DBF4 has been shown to interact with:
References
- 1 2 Kumagai H, Sato N, Yamada M, Mahony D, Seghezzi W, Lees E, Arai K, Masai H (Jul 1999). "A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells". Molecular and Cellular Biology 19 (7): 5083–95. PMC 84351. PMID 10373557.
- ↑ Lepke M, Pütter V, Staib C, Kneissl M, Berger C, Hoehn K, Nanda I, Schmid M, Grummt F (Sep 1999). "Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes". Molecular & General Genetics 262 (2): 220–9. doi:10.1007/s004380051078. PMID 10517317.
- ↑ "Entrez Gene: DBF4 DBF4 homolog (S. cerevisiae)".
- 1 2 3 4 5 Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.
- ↑ Jiang W, McDonald D, Hope TJ, Hunter T (Oct 1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". The EMBO Journal 18 (20): 5703–13. doi:10.1093/emboj/18.20.5703. PMC 1171637. PMID 10523313.
Further reading
- Jiang W, McDonald D, Hope TJ, Hunter T (Oct 1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". The EMBO Journal 18 (20): 5703–13. doi:10.1093/emboj/18.20.5703. PMC 1171637. PMID 10523313.
- Yamada M, Sato N, Taniyama C, Ohtani K, Arai K, Masai H (Aug 2002). "A 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinase". The Journal of Biological Chemistry 277 (31): 27668–81. doi:10.1074/jbc.M202884200. PMID 12015319.
- Wu X, Lee H (Nov 2002). "Human Dbf4/ASK promoter is activated through the Sp1 and MluI cell-cycle box (MCB) transcription elements". Oncogene 21 (51): 7786–96. doi:10.1038/sj.onc.1205914. PMID 12420215.
- Duncker BP, Shimada K, Tsai-Pflugfelder M, Pasero P, Gasser SM (Dec 2002). "An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing". Proceedings of the National Academy of Sciences of the United States of America 99 (25): 16087–92. doi:10.1073/pnas.252093999. PMC 138569. PMID 12441400.
- Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J (Jan 2003). "An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication". Molecular Cell 11 (1): 203–13. doi:10.1016/S1097-2765(02)00799-2. PMID 12535533.
- Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. PMID 12614612.
- Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Schnepp RW, Hou Z, Wang H, Petersen C, Silva A, Masai H, Hua X (Sep 2004). "Functional interaction between tumor suppressor menin and activator of S-phase kinase". Cancer Research 64 (18): 6791–6. doi:10.1158/0008-5472.CAN-04-0724. PMID 15374998.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gérard A, Koundrioukoff S, Ramillon V, Sergère JC, Mailand N, Quivy JP, Almouzni G (Aug 2006). "The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen". EMBO Reports 7 (8): 817–23. doi:10.1038/sj.embor.7400750. PMC 1525143. PMID 16826239.
- Tsuji T, Ficarro SB, Jiang W (Oct 2006). "Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells". Molecular Biology of the Cell 17 (10): 4459–72. doi:10.1091/mbc.E06-03-0241. PMC 1635350. PMID 16899510.
- Heffernan TP, Unsal-Kaçmaz K, Heinloth AN, Simpson DA, Paules RS, Sancar A, Cordeiro-Stone M, Kaufmann WK (Mar 2007). "Cdc7-Dbf4 and the human S checkpoint response to UVC". The Journal of Biological Chemistry 282 (13): 9458–68. doi:10.1074/jbc.M611292200. PMC 1839878. PMID 17276990.
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