DNA damage-binding protein

damage-specific DNA binding protein 1, 127kDa
Identifiers
Symbol DDB1
Alt. symbols XPE
Entrez 1642
HUGO 2717
OMIM 600045
RefSeq NM_001923
UniProt Q16531
Other data
Locus Chr. 11 q12-q13
damage-specific DNA binding protein 2, 48kDa
Identifiers
Symbol DDB2
Alt. symbols DBB, UV-DDB2, FLJ34321
Entrez 1643
HUGO 2718
OMIM 600811
RefSeq NM_000107
UniProt Q92466
Other data
Locus Chr. 11 p12-p11

DNA damage-binding protein is a protein complex that is responsible for repair of UV-damaged DNA.[1] This complex is composed of two protein subunits, a large subunit DDB1 and a small subunit DDB2. This complex functions in nucleotide excision repair.

References

  1. Dualan R, Brody T, Keeney S, Nichols AF, Admon A, Linn S (Feb 1996). "Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein". Genomics 29 (1): 62–9. doi:10.1006/geno.1995.1215. PMID 8530102.
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