DPYS

Dihydropyrimidinase
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2VR2​
Identifiers
Symbols	DPYS ; DHP; DHPase
External IDs	OMIM: 613326 MGI: 1928679 HomoloGene: 20359 ChEMBL: 2465 GeneCards: DPYS Gene
EC number	3.5.2.2
Gene ontology Molecular function • uracil binding • thymine binding • dihydropyrimidinase activity • zinc ion binding • amino acid binding • phosphoprotein binding Cellular component • cytosol • extracellular exosome Biological process • pyrimidine nucleobase metabolic process • pyrimidine nucleobase catabolic process • thymine catabolic process • uracil catabolic process • beta-alanine metabolic process • small molecule metabolic process • pyrimidine nucleoside catabolic process • protein homotetramerization • nucleobase-containing small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1807	64705
Ensembl	ENSG00000147647	ENSMUSG00000022304
UniProt	Q14117	Q9EQF5
RefSeq (mRNA)	NM_001385	NM_001164466
RefSeq (protein)	NP_001376	NP_001157938
Location (UCSC)	Chr 8: 104.33 – 104.47 Mb	Chr 15: 39.77 – 39.86 Mb
PubMed search

Dihydropyrimidinase is an enzyme that in humans is encoded by the DPYS gene.^[1][2]

Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.^[2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

1. Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene 180 (1-2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
2. "Entrez Gene: DPYS dihydropyrimidinase".

Further reading

• Thomas HR, Ezzeldin HH, Guarcello V; et al. (2008). "Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism.". Pharmacogenet. Genomics 18 (1): 25–35. doi:10.1097/FPC.0b013e3282f2f134. PMID 18216719.
• Thomas HR, Ezzeldin HH, Guarcello V; et al. (2008). "Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism.". Pharmacogenet. Genomics 17 (11): 973–87. doi:10.1097/FPC.0b013e3282f01788. PMID 18075467.
• van Kuilenburg AB, Meijer J, Dobritzsch D; et al. (2007). "Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency.". Mol. Genet. Metab. 91 (2): 157–64. doi:10.1016/j.ymgme.2007.02.008. PMID 17383919.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fukada M, Watakabe I, Yuasa-Kawada J; et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family.". J. Biol. Chem. 275 (48): 37957–65. doi:10.1074/jbc.M003277200. PMID 10956643.
• Hamajima N, Kouwaki M, Vreken P; et al. (1998). "Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene.". Am. J. Hum. Genet. 63 (3): 717–26. doi:10.1086/302022. PMC 1377410. PMID 9718352.
• Naguib FN, el Kouni MH, Cha S (1985). "Enzymes of uracil catabolism in normal and neoplastic human tissues.". Cancer Res. 45 (11 Pt 1): 5405–12. PMID 3931905.